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Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma.
Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, Schaefer M, Gohla A, Harteneck C, Wymann MP, Jeanclos E, Nürnberg B. Kurig B, et al. Among authors: shymanets a. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20312-7. doi: 10.1073/pnas.0905506106. Epub 2009 Nov 11. Proc Natl Acad Sci U S A. 2009. PMID: 19906996 Free PMC article.
Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.
Shymanets A, Prajwal, Vadas O, Czupalla C, LoPiccolo J, Brenowitz M, Ghigo A, Hirsch E, Krause E, Wetzker R, Williams RL, Harteneck C, Nürnberg B. Shymanets A, et al. Biochem J. 2015 Jul 1;469(1):59-69. doi: 10.1042/BJ20150099. Biochem J. 2015. PMID: 26173259 Free PMC article.
G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.
Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, Backer JM. Dbouk HA, et al. Among authors: shymanets a. Sci Signal. 2012 Dec 4;5(253):ra89. doi: 10.1126/scisignal.2003264. Sci Signal. 2012. PMID: 23211529 Free PMC article.
A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion.
Heitz SD, Hamelin DJ, Hoffmann RM, Greenberg N, Salloum G, Erami Z, Khalil BD, Shymanets A, Steidle EA, Gong GQ, Nürnberg B, Burke JE, Flanagan JU, Bresnick AR, Backer JM. Heitz SD, et al. Among authors: shymanets a. J Biol Chem. 2019 Mar 22;294(12):4621-4633. doi: 10.1074/jbc.RA118.006032. Epub 2019 Jan 18. J Biol Chem. 2019. PMID: 30659094 Free PMC article.
17 results