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Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation.
Kaplanov I, Carmi Y, Kornetsky R, Shemesh A, Shurin GV, Shurin MR, Dinarello CA, Voronov E, Apte RN. Kaplanov I, et al. Among authors: shurin gv, shurin mr. Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1361-1369. doi: 10.1073/pnas.1812266115. Epub 2018 Dec 13. Proc Natl Acad Sci U S A. 2019. PMID: 30545915 Free PMC article. Clinical Trial.
Tumor's other immune targets: dendritic cells.
Esche C, Lokshin A, Shurin GV, Gastman BR, Rabinowich H, Watkins SC, Lotze MT, Shurin MR. Esche C, et al. Among authors: shurin gv, shurin mr. J Leukoc Biol. 1999 Aug;66(2):336-44. doi: 10.1002/jlb.66.2.336. J Leukoc Biol. 1999. PMID: 10449178
179 results