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New approach methodologies (NAMs) for human-relevant biokinetics predictions. Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment.
Punt A, Bouwmeester H, Blaauboer BJ, Coecke S, Hakkert B, Hendriks DFG, Jennings P, Kramer NI, Neuhoff S, Masereeuw R, Paini A, Peijnenburg AACM, Rooseboom M, Shuler ML, Sorrell I, Spee B, Strikwold M, Van der Meer AD, Van der Zande M, Vinken M, Yang H, Bos PMJ, Heringa MB. Punt A, et al. Among authors: shuler ml. ALTEX. 2020;37(4):607-622. doi: 10.14573/altex.2003242. Epub 2020 Jun 8. ALTEX. 2020. PMID: 32521035 Free article.
Body-on-a-chip systems for animal-free toxicity testing.
Mahler GJ, Esch MB, Stokol T, Hickman JJ, Shuler ML. Mahler GJ, et al. Among authors: shuler ml. Altern Lab Anim. 2016 Oct;44(5):469-478. doi: 10.1177/026119291604400508. Altern Lab Anim. 2016. PMID: 27805830 Review.
Self-contained, low-cost Body-on-a-Chip systems for drug development.
Wang YI, Oleaga C, Long CJ, Esch MB, McAleer CW, Miller PG, Hickman JJ, Shuler ML. Wang YI, et al. Among authors: shuler ml. Exp Biol Med (Maywood). 2017 Nov;242(17):1701-1713. doi: 10.1177/1535370217694101. Epub 2017 Feb 17. Exp Biol Med (Maywood). 2017. PMID: 29065797 Free PMC article. Review.
Recent Advances in Body-on-a-Chip Systems.
Sung JH, Wang YI, Narasimhan Sriram N, Jackson M, Long C, Hickman JJ, Shuler ML. Sung JH, et al. Among authors: shuler ml. Anal Chem. 2019 Jan 2;91(1):330-351. doi: 10.1021/acs.analchem.8b05293. Epub 2018 Dec 11. Anal Chem. 2019. PMID: 30472828 Free PMC article. Review. No abstract available.
Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs.
Oleaga C, Bernabini C, Smith AS, Srinivasan B, Jackson M, McLamb W, Platt V, Bridges R, Cai Y, Santhanam N, Berry B, Najjar S, Akanda N, Guo X, Martin C, Ekman G, Esch MB, Langer J, Ouedraogo G, Cotovio J, Breton L, Shuler ML, Hickman JJ. Oleaga C, et al. Among authors: shuler ml. Sci Rep. 2016 Feb 3;6:20030. doi: 10.1038/srep20030. Sci Rep. 2016. PMID: 26837601 Free PMC article.
251 results