Shu YZ - Search Results

1

Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement.

Li W, Zhao W, Liu X, Huang X, Lopez OD, Leet JE, Fancher RM, Nguyen V, Goodrich J, Easter J, Hong Y, Caceres-Cortes J, Chang SY, Ma L, Belema M, Hamann LG, Gao M, Zhu M, Shu YZ, Humphreys WG, Johnson BM. Li W, et al. Among authors: shu yz. Drug Metab Dispos. 2016 Jun;44(6):809-20. doi: 10.1124/dmd.115.068866. Epub 2016 Mar 30. Drug Metab Dispos. 2016. PMID: 27029743

2

Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.

Zhuo X, Zhao W, Zheng J, Humphreys WG, Shu YZ, Zhu M. Zhuo X, et al. Among authors: shu yz. Chem Biol Interact. 2009 Oct 7;181(2):227-35. doi: 10.1016/j.cbi.2009.06.017. Epub 2009 Jul 2. Chem Biol Interact. 2009. PMID: 19576871

3

Comparative biotransformation of pyrazinone-containing corticotropin-releasing factor receptor-1 antagonists: minimizing the reactive metabolite formation.

Zhuo X, Hartz RA, Bronson JJ, Wong H, Ahuja VT, Vrudhula VM, Leet JE, Huang S, Macor JE, Shu YZ. Zhuo X, et al. Among authors: shu yz. Drug Metab Dispos. 2010 Jan;38(1):5-15. doi: 10.1124/dmd.109.028910. Drug Metab Dispos. 2010. PMID: 19833844

4

Metabolism of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): identification of an unusual N-acetylglucosamine conjugate in the cynomolgus monkey.

Johnson BM, Kamath AV, Leet JE, Liu X, Bhide RS, Tejwani RW, Zhang Y, Qian L, Wei DD, Lombardo LJ, Shu YZ. Johnson BM, et al. Among authors: shu yz. Drug Metab Dispos. 2008 Dec;36(12):2475-83. doi: 10.1124/dmd.108.022624. Epub 2008 Sep 11. Drug Metab Dispos. 2008. PMID: 18787055

5

Identification of human liver microsomal proteins adducted by a reactive metabolite using shotgun proteomics.

Yang Y, Xiao Q, Humphreys WG, Dongre A, Shu YZ. Yang Y, et al. Among authors: shu yz. Chem Res Toxicol. 2014 Sep 15;27(9):1537-46. doi: 10.1021/tx500181p. Epub 2014 Aug 19. Chem Res Toxicol. 2014. PMID: 25105203

6

Identification of glutathione conjugates of acetylene-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5.

Zhuo X, Huang XS, Degnan AP, Snyder LB, Yang F, Huang H, Shu YZ, Johnson BM. Zhuo X, et al. Among authors: shu yz. Drug Metab Dispos. 2015 Apr;43(4):578-89. doi: 10.1124/dmd.114.061879. Epub 2015 Jan 29. Drug Metab Dispos. 2015. PMID: 25633841

7

Rosuvastatin Liver Partitioning in Cynomolgus Monkeys: Measurement In Vivo and Prediction Using In Vitro Monkey Hepatocyte Uptake.

Morse BL, Cai H, MacGuire JG, Fox M, Zhang L, Zhang Y, Gu X, Shen H, Dierks EA, Su H, Luk CE, Marathe P, Shu YZ, Humphreys WG, Lai Y. Morse BL, et al. Among authors: shu yz. Drug Metab Dispos. 2015 Nov;43(11):1788-94. doi: 10.1124/dmd.115.065946. Epub 2015 Sep 4. Drug Metab Dispos. 2015. PMID: 26341276

8

Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery.

Shu YZ, Johnson BM, Yang TJ. Shu YZ, et al. AAPS J. 2008;10(1):178-92. doi: 10.1208/s12248-008-9016-9. Epub 2008 Mar 13. AAPS J. 2008. PMID: 18446518 Free PMC article. Review.

9

Bioactivation of 2-(alkylthio)-1,3,4-thiadiazoles and 2-(alkylthio)-1,3-benzothiazoles.

Yang Y, Qiu F, Josephs JL, Humphreys WG, Shu YZ. Yang Y, et al. Among authors: shu yz. Chem Res Toxicol. 2012 Dec 17;25(12):2770-9. doi: 10.1021/tx3003998. Epub 2012 Nov 30. Chem Res Toxicol. 2012. PMID: 23148672

10

High-resolution mass spectrometry-based background subtraction for identifying protein modifications in a complex biological system: detection of acetaminophen-bound microsomal proteins including argininosuccinate synthetase.

Zhang H, Gan J, Shu YZ, Humphreys WG. Zhang H, et al. Among authors: shu yz. Chem Res Toxicol. 2015 Apr 20;28(4):775-81. doi: 10.1021/tx500526s. Epub 2015 Feb 16. Chem Res Toxicol. 2015. PMID: 25654186

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