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A novel tumor suppressor encoded by a 1p36.3 lncRNA functions as a phosphoinositide-binding protein repressing AKT phosphorylation/activation and promoting autophagy.
Li L, Shu XS, Geng H, Ying J, Guo L, Luo J, Xiang T, Wu L, Ma BBY, Chan ATC, Zhu X, Ambinder RF, Tao Q. Li L, et al. Among authors: shu xs. Cell Death Differ. 2023 May;30(5):1166-1183. doi: 10.1038/s41418-023-01129-w. Epub 2023 Feb 23. Cell Death Differ. 2023. PMID: 36813924 Free PMC article.
CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis.
Wang Y, Li J, Cui Y, Li T, Ng KM, Geng H, Li H, Shu XS, Li H, Liu W, Luo B, Zhang Q, Mok TS, Zheng W, Qiu X, Srivastava G, Yu J, Sung JJ, Chan AT, Ma D, Tao Q, Han W. Wang Y, et al. Among authors: shu xs. Cancer Res. 2009 Jun 15;69(12):5194-201. doi: 10.1158/0008-5472.CAN-08-3694. Epub 2009 Jun 9. Cancer Res. 2009. PMID: 19509237
Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting β-catenin and AKT signaling but frequently methylated in common carcinomas.
Li L, Ying J, Tong X, Zhong L, Su X, Xiang T, Shu X, Rong R, Xiong L, Li H, Chan AT, Ambinder RF, Guo Y, Tao Q. Li L, et al. Cell Mol Life Sci. 2014 Jun;71(11):2179-92. doi: 10.1007/s00018-013-1485-z. Epub 2013 Oct 25. Cell Mol Life Sci. 2014. PMID: 24158497
43 results