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Optimized immunosuppression to prevent graft failure in renal transplant recipients with HLA antibodies (OuTSMART): a randomised controlled trial.
Stringer D, Gardner L, Shaw O, Clarke B, Briggs D, Worthington J, Buckland M, Danzi G, Hilton R, Picton M, Thuraisingham R, Borrows R, Baker R, McCullough K, Stoves J, Phanish M, Shah S, Shiu KY, Walsh SB, Ahmed A, Ayub W, Hegarty J, Tinch-Taylor R, Georgiou E, Bidad N, Kılıç A, Moon Z, Horne R, McCrone P, Kelly J, Murphy C, Peacock J, Dorling A. Stringer D, et al. Among authors: shiu ky. EClinicalMedicine. 2023 Jan 12;56:101819. doi: 10.1016/j.eclinm.2022.101819. eCollection 2023 Feb. EClinicalMedicine. 2023. PMID: 36684392 Free PMC article.
Update to the study protocol, including statistical analysis plan, for the multicentre, randomised controlled OuTSMART trial: a combined screening/treatment programme to prevent premature failure of renal transplants due to chronic rejection in patients with HLA antibodies.
Stringer D, Gardner LM, Peacock JL, Rebollo-Mesa I, Hilton R, Shaw O, Baker R, Clark B, Thuraisingham RC, Buckland M, Picton M, Worthington J, Borrows R, Briggs D, Shah S, Shiu KY, McCullough K, Phanish M, Hegarty J, Stoves J, Ahmed A, Ayub W, Horne R, McCrone P, Kelly J, Murphy C, Dorling A. Stringer D, et al. Among authors: shiu ky. Trials. 2019 Aug 5;20(1):476. doi: 10.1186/s13063-019-3602-2. Trials. 2019. PMID: 31383029 Free PMC article.
Effect of Optimized Immunosuppression (Including Rituximab) on Anti-Donor Alloresponses in Patients With Chronically Rejecting Renal Allografts.
Shiu KY, Stringer D, McLaughlin L, Shaw O, Brookes P, Burton H, Wilkinson H, Douthwaite H, Tsui TL, Mclean A, Hilton R, Griffin S, Geddes C, Ball S, Baker R, Roufosse C, Horsfield C, Dorling A. Shiu KY, et al. Front Immunol. 2020 Feb 5;11:79. doi: 10.3389/fimmu.2020.00079. eCollection 2020. Front Immunol. 2020. PMID: 32117242 Free PMC article. Clinical Trial.
Graft dysfunction in chronic antibody-mediated rejection correlates with B-cell-dependent indirect antidonor alloresponses and autocrine regulation of interferon-γ production by Th1 cells.
Shiu KY, McLaughlin L, Rebollo-Mesa I, Zhao J, Burton H, Douthwaite H, Wilkinson H, Semik V, Dodd PC, Brookes P, Lechler RI, Hernandez-Fuentes MP, Kemper C, Dorling A. Shiu KY, et al. Kidney Int. 2017 Feb;91(2):477-492. doi: 10.1016/j.kint.2016.10.009. Epub 2016 Dec 15. Kidney Int. 2017. PMID: 27988211 Free PMC article.