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The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase-leukotriene B4 axis.
Hosooka T, Hosokawa Y, Matsugi K, Shinohara M, Senga Y, Tamori Y, Aoki C, Matsui S, Sasaki T, Kitamura T, Kuroda M, Sakaue H, Nomura K, Yoshino K, Nabatame Y, Itoh Y, Yamaguchi K, Hayashi Y, Nakae J, Accili D, Yokomizo T, Seino S, Kasuga M, Ogawa W. Hosooka T, et al. Among authors: shinohara m. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11674-11684. doi: 10.1073/pnas.1921015117. Epub 2020 May 11. Proc Natl Acad Sci U S A. 2020. PMID: 32393635 Free PMC article.
Gut Microbiome and Plasma Microbiome-Related Metabolites in Patients With Decompensated and Compensated Heart Failure.
Hayashi T, Yamashita T, Watanabe H, Kami K, Yoshida N, Tabata T, Emoto T, Sasaki N, Mizoguchi T, Irino Y, Toh R, Shinohara M, Okada Y, Ogawa W, Yamada T, Hirata KI. Hayashi T, et al. Among authors: shinohara m. Circ J. 2018 Dec 25;83(1):182-192. doi: 10.1253/circj.CJ-18-0468. Epub 2018 Nov 29. Circ J. 2018. PMID: 30487369 Free article. Clinical Trial.
Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity.
Yoshida N, Yamashita T, Osone T, Hosooka T, Shinohara M, Kitahama S, Sasaki K, Sasaki D, Yoneshiro T, Suzuki T, Emoto T, Saito Y, Ozawa G, Hirota Y, Kitaura Y, Shimomura Y, Okamatsu-Ogura Y, Saito M, Kondo A, Kajimura S, Inagaki T, Ogawa W, Yamada T, Hirata KI. Yoshida N, et al. Among authors: shinohara m. iScience. 2021 Oct 24;24(11):103342. doi: 10.1016/j.isci.2021.103342. eCollection 2021 Nov 19. iScience. 2021. PMID: 34805797 Free PMC article.
Trans-fatty acid promotes thrombus formation in mice by aggravating antithrombogenic endothelial functions via Toll-like receptors.
Kondo K, Ishida T, Yasuda T, Nakajima H, Mori K, Tanaka N, Mori T, Monguchi T, Shinohara M, Irino Y, Toh R, Rikitake Y, Kiyomizu K, Tomiyama Y, Yamamoto J, Hirata K. Kondo K, et al. Among authors: shinohara m. Mol Nutr Food Res. 2015 Apr;59(4):729-40. doi: 10.1002/mnfr.201400537. Epub 2015 Jan 27. Mol Nutr Food Res. 2015. PMID: 25546502
Pemafibrate, A Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator, Reduces Plasma Eicosanoid Levels and Ameliorates Endothelial Dysfunction in Diabetic Mice.
Suto K, Fukuda D, Shinohara M, Ganbaatar B, Yagi S, Kusunose K, Yamada H, Soeki T, Hirata KI, Sata M. Suto K, et al. Among authors: shinohara m. J Atheroscler Thromb. 2021 Dec 1;28(12):1349-1360. doi: 10.5551/jat.61101. Epub 2021 Mar 27. J Atheroscler Thromb. 2021. PMID: 33775978 Free PMC article.
1,484 results