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Increased Remyelination and Proregenerative Microglia Under Siponimod Therapy in Mechanistic Models.
Dietrich M, Hecker C, Martin E, Langui D, Gliem M, Stankoff B, Lubetzki C, Gruchot J, Göttle P, Issberner A, Nasiri M, Ramseier P, Beerli C, Tisserand S, Beckmann N, Shimshek D, Petzsch P, Akbar D, Levkau B, Stark H, Köhrer K, Hartung HP, Küry P, Meuth SG, Bigaud M, Zalc B, Albrecht P. Dietrich M, et al. Among authors: shimshek d. Neurol Neuroimmunol Neuroinflamm. 2022 Mar 30;9(3):e1161. doi: 10.1212/NXI.0000000000001161. Print 2022 May. Neurol Neuroimmunol Neuroinflamm. 2022. PMID: 35354603 Free PMC article.
Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model.
Beckmann N, Neuhaus A, Zurbruegg S, Volkmer P, Patino C, Joller S, Feuerbach D, Doelemeyer A, Schweizer T, Rudin S, Neumann U, Berth R, Frieauff W, Gasparini F, Shimshek DR. Beckmann N, et al. Among authors: shimshek dr. J Neuroinflammation. 2023 Feb 8;20(1):29. doi: 10.1186/s12974-022-02671-z. J Neuroinflammation. 2023. PMID: 36755323 Free PMC article.
Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units.
Giorgetti E, Panesar M, Zhang Y, Joller S, Ronco M, Obrecht M, Lambert C, Accart N, Beckmann N, Doelemeyer A, Perrot L, Fruh I, Mueller M, Pierrel E, Summermatter S, Bidinosti M, Shimshek DR, Brachat S, Nash M. Giorgetti E, et al. Cell Rep. 2019 Nov 5;29(6):1539-1554.e7. doi: 10.1016/j.celrep.2019.10.003. Cell Rep. 2019. PMID: 31693894 Free article.
Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer's disease.
Dhandapani R, Neri M, Bernhard M, Brzak I, Schweizer T, Rudin S, Joller S, Berth R, Kernen J, Neuhaus A, Waldt A, Cuttat R, Naumann U, Keller CG, Roma G, Feuerbach D, Shimshek DR, Neumann U, Gasparini F, Galimberti I. Dhandapani R, et al. Among authors: shimshek dr. Cell Rep. 2022 May 31;39(9):110883. doi: 10.1016/j.celrep.2022.110883. Cell Rep. 2022. PMID: 35649351 Free article.
Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor-treated APP transgenic mice.
Beckmann N, Doelemeyer A, Zurbruegg S, Bigot K, Theil D, Frieauff W, Kolly C, Moulin P, Neddermann D, Kreutzer R, Perrot L, Brzak I, Jacobson LH, Staufenbiel M, Neumann U, Shimshek DR. Beckmann N, et al. Among authors: shimshek dr. Neurobiol Aging. 2016 Sep;45:50-60. doi: 10.1016/j.neurobiolaging.2016.05.009. Epub 2016 May 17. Neurobiol Aging. 2016. PMID: 27459925 Free article.
The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease.
Neumann U, Ufer M, Jacobson LH, Rouzade-Dominguez ML, Huledal G, Kolly C, Lüönd RM, Machauer R, Veenstra SJ, Hurth K, Rueeger H, Tintelnot-Blomley M, Staufenbiel M, Shimshek DR, Perrot L, Frieauff W, Dubost V, Schiller H, Vogg B, Beltz K, Avrameas A, Kretz S, Pezous N, Rondeau JM, Beckmann N, Hartmann A, Vormfelde S, David OJ, Galli B, Ramos R, Graf A, Lopez Lopez C. Neumann U, et al. EMBO Mol Med. 2018 Nov;10(11):e9316. doi: 10.15252/emmm.201809316. EMBO Mol Med. 2018. PMID: 30224383 Free PMC article. Clinical Trial.
Early Aβ reduction prevents progression of cerebral amyloid angiopathy.
Schelle J, Wegenast-Braun BM, Fritschi SK, Kaeser SA, Jährling N, Eicke D, Skodras A, Beschorner N, Obermueller U, Häsler LM, Wolfer DP, Mueggler T, Shimshek DR, Neumann U, Dodt HU, Staufenbiel M, Jucker M. Schelle J, et al. Among authors: shimshek dr. Ann Neurol. 2019 Oct;86(4):561-571. doi: 10.1002/ana.25562. Epub 2019 Aug 19. Ann Neurol. 2019. PMID: 31359452
56 results