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Ortho group activation of a bromopyrrole ester in Suzuki-Miyaura cross-coupling reactions: Application to the synthesis of new microtubule depolymerizing agents with potent cytotoxic activities.
Gupton JT, Yeudall S, Telang N, Hoerrner M, Huff E, Crawford E, Lounsbury K, Kimmel M, Curry W, Harrison A, Juekun W, Shimozono A, Ortolani J, Lescalleet K, Patteson J, Moore-Stoll V, Rohena CC, Mooberry SL, Obaidullah AJ, Kellogg GE, Sikorski JA. Gupton JT, et al. Among authors: shimozono a. Bioorg Med Chem. 2017 Jun 15;25(12):3206-3214. doi: 10.1016/j.bmc.2017.04.012. Epub 2017 Apr 11. Bioorg Med Chem. 2017. PMID: 28433513 Free PMC article.
Application of vinylogous carbamates and vinylogous aminonitriles to the regiospecific synthesis of uniquely functionalized pyrroles and quinolones.
Gupton JT, Crawford E, Mahoney M, Clark E, Curry W, Lane A, Shimozono A, Moore-Stoll V, Elofson K, Juekun W, Newton M, Yeudall S, Jaekle E, Kanters R, Sikorski JA. Gupton JT, et al. Among authors: shimozono a. Tetrahedron. 2018 Dec 27;74(52):7408-7420. doi: 10.1016/j.tet.2018.10.078. Epub 2018 Nov 5. Tetrahedron. 2018. PMID: 31289413 Free PMC article.
Further studies on the application of vinylogous amides and β-halovinylaldehydes to the regiospecific synthesis of unsymmetrical, polyfunctionalized 2,3,4- and 1,2,3,4- substituted pyrroles.
Gupton JT, Shimozono A, Crawford E, Ortolani J, Clark E, Mahoney M, Heese C, Noble J, Mandry CP, Kanters R, Dominey RN, Goldman EW, Sikorski JA, Fisher DC. Gupton JT, et al. Among authors: shimozono a. Tetrahedron. 2018 May 24;74(21):2650-2663. doi: 10.1016/j.tet.2018.04.017. Epub 2018 Apr 7. Tetrahedron. 2018. PMID: 30344350 Free PMC article.
Select β- and γ-branched 1-alkylpyrazol-4-yl methylcarbamates exhibit high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.
Carlier PR, Chen QH, Verma A, Wong DM, Mutunga JM, Müller J, Islam R, Shimozono AM, Tong F, Li J, Totrov M, Bloomquist JR. Carlier PR, et al. Among authors: shimozono am. Pestic Biochem Physiol. 2018 Oct;151:32-39. doi: 10.1016/j.pestbp.2018.02.003. Epub 2018 Feb 13. Pestic Biochem Physiol. 2018. PMID: 30524149 Free PMC article.
Nickel-Catalyzed Conversion of Enol Triflates into Alkenyl Halides.
Hofstra JL, Poremba KE, Shimozono AM, Reisman SE. Hofstra JL, et al. Among authors: shimozono am. Angew Chem Int Ed Engl. 2019 Oct 14;58(42):14901-14905. doi: 10.1002/anie.201906815. Epub 2019 Sep 19. Angew Chem Int Ed Engl. 2019. PMID: 31410936 Free PMC article.