A randomly integrated transgenic H19 imprinting control region acquires methylation imprinting independently of its establishment in germ cells.
Matsuzaki H, Okamura E, Shimotsuma M, Fukamizu A, Tanimoto K.
Matsuzaki H, et al. Among authors: shimotsuma m.
Mol Cell Biol. 2009 Sep;29(17):4595-603. doi: 10.1128/MCB.00275-09. Epub 2009 Jun 22.
Mol Cell Biol. 2009.
PMID: 19546235
Free PMC article.
By grafting a 2.9-kbp H19 ICR fragment into a human beta-globin yeast artificial chromosome in transgenic mice, we previously showed that the ICR could recapitulate imprinted methylation and expression at a heterologous locus, suggesting that the H19 ICR in the beta-globin locus …
By grafting a 2.9-kbp H19 ICR fragment into a human beta-globin yeast artificial chromosome in transgenic mice, we previously showed that th …