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ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells.
Yamamoto J, Suwa T, Murase Y, Tateno S, Mizutome H, Asatsuma-Okumura T, Shimizu N, Kishi T, Momose S, Kizaki M, Ito T, Yamaguchi Y, Handa H. Yamamoto J, et al. Among authors: shimizu n. Nat Chem Biol. 2020 Nov;16(11):1208-1217. doi: 10.1038/s41589-020-0645-3. Epub 2020 Sep 21. Nat Chem Biol. 2020. PMID: 32958952
p63 is a cereblon substrate involved in thalidomide teratogenicity.
Asatsuma-Okumura T, Ando H, De Simone M, Yamamoto J, Sato T, Shimizu N, Asakawa K, Yamaguchi Y, Ito T, Guerrini L, Handa H. Asatsuma-Okumura T, et al. Among authors: shimizu n. Nat Chem Biol. 2019 Nov;15(11):1077-1084. doi: 10.1038/s41589-019-0366-7. Epub 2019 Oct 7. Nat Chem Biol. 2019. PMID: 31591562
Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish.
Yatsuka H, Hada K, Shiraishi H, Umeda R, Morisaki I, Urushibata H, Shimizu N, Sebastian WA, Hikida T, Ishitani T, Hanada R, Shimada T, Kimoto K, Kubota T, Hanada T. Yatsuka H, et al. Among authors: shimizu n. Biochem Biophys Res Commun. 2020 Dec 17;533(4):1470-1476. doi: 10.1016/j.bbrc.2020.10.044. Epub 2020 Oct 24. Biochem Biophys Res Commun. 2020. PMID: 33333712
Modeling a human CLP1 mutation in mouse identifies an accumulation of tyrosine pre-tRNA fragments causing pontocerebellar hypoplasia type 10.
Morisaki I, Shiraishi H, Fujinami H, Shimizu N, Hikida T, Arai Y, Kobayashi T, Hanada R, Penninger JM, Fujiki M, Hanada T. Morisaki I, et al. Among authors: shimizu n. Biochem Biophys Res Commun. 2021 Sep 17;570:60-66. doi: 10.1016/j.bbrc.2021.07.036. Epub 2021 Jul 14. Biochem Biophys Res Commun. 2021. PMID: 34273619
Ankle2 deficiency-associated microcephaly and spermatogenesis defects in zebrafish are alleviated by heterozygous deletion of vrk1.
Apridita Sebastian W, Shiraishi H, Shimizu N, Umeda R, Lai S, Ikeuchi M, Morisaki I, Yano S, Yoshimura A, Hanada R, Hanada T. Apridita Sebastian W, et al. Among authors: shimizu n. Biochem Biophys Res Commun. 2022 Oct 8;624:95-101. doi: 10.1016/j.bbrc.2022.07.070. Epub 2022 Jul 31. Biochem Biophys Res Commun. 2022. PMID: 35940133
3,198 results