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Further reduction in adenovirus vector-mediated liver transduction without largely affecting transgene expression in target organ by exploiting microrna-mediated regulation and the Cre-loxP recombination system.
Bennett D, Sakurai F, Shimizu K, Matsui H, Tomita K, Suzuki T, Katayama K, Kawabata K, Mizuguchi H. Bennett D, et al. Among authors: shimizu k. Mol Pharm. 2012 Dec 3;9(12):3452-63. doi: 10.1021/mp300248u. Epub 2012 Nov 12. Mol Pharm. 2012. PMID: 23127182
Adenovirus Vector-Derived VA-RNA-Mediated Innate Immune Responses.
Machitani M, Yamaguchi T, Shimizu K, Sakurai F, Katayama K, Kawabata K, Mizuguchi H. Machitani M, et al. Among authors: shimizu k. Pharmaceutics. 2011 Jul 11;3(3):338-53. doi: 10.3390/pharmaceutics3030338. Pharmaceutics. 2011. PMID: 24310584 Free PMC article.
Development of mice exhibiting hepatic microsomal activity of human CYP3A4 comparable to that in human liver microsomes by intravenous administration of an adenovirus vector expressing human CYP3A4.
Kuno S, Sakurai F, Shimizu K, Matsumura N, Kim S, Watanabe H, Tashiro K, Tachibana M, Yokoi T, Mizuguchi H. Kuno S, et al. Among authors: shimizu k. Drug Metab Pharmacokinet. 2014;29(4):296-304. doi: 10.2133/dmpk.dmpk-13-rg-109. Epub 2014 Feb 4. Drug Metab Pharmacokinet. 2014. PMID: 24492672 Free article.
7,175 results