Shimada K - Search Results

1

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.

Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, Chen S, Boskovic ZV, Javaid S, Huang C, Wu X, Tseng YY, Roider EM, Gao D, Cleary JM, Wolpin BM, Mesirov JP, Haber DA, Engelman JA, Boehm JS, Kotz JD, Hon CS, Chen Y, Hahn WC, Levesque MP, Doench JG, Berens ME, Shamji AF, Clemons PA, Stockwell BR, Schreiber SL. Viswanathan VS, et al. Among authors: shimada k. Nature. 2017 Jul 27;547(7664):453-457. doi: 10.1038/nature23007. Epub 2017 Jul 5. Nature. 2017. PMID: 28678785 Free PMC article.

2

Regulation of ferroptotic cancer cell death by GPX4.

Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR. Yang WS, et al. Among authors: shimada k. Cell. 2014 Jan 16;156(1-2):317-331. doi: 10.1016/j.cell.2013.12.010. Cell. 2014. PMID: 24439385 Free PMC article.

3

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis.

Shimada K, Skouta R, Kaplan A, Yang WS, Hayano M, Dixon SJ, Brown LM, Valenzuela CA, Wolpaw AJ, Stockwell BR. Shimada K, et al. Nat Chem Biol. 2016 Jul;12(7):497-503. doi: 10.1038/nchembio.2079. Epub 2016 May 9. Nat Chem Biol. 2016. PMID: 27159577 Free PMC article.

4

tRNA synthase suppression activates de novo cysteine synthesis to compensate for cystine and glutathione deprivation during ferroptosis.

Shimada K, Stockwell BR. Shimada K, et al. Mol Cell Oncol. 2015 Oct 6;3(2):e1091059. doi: 10.1080/23723556.2015.1091059. eCollection 2016 Mar. Mol Cell Oncol. 2015. PMID: 27308611 Free PMC article.

5

Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death.

Skouta R, Hayano M, Shimada K, Stockwell BR. Skouta R, et al. Among authors: shimada k. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5707-13. doi: 10.1016/j.bmcl.2012.06.077. Epub 2012 Jun 30. Bioorg Med Chem Lett. 2012. PMID: 22832321 Free PMC article.

6

Cell-Line Selectivity Improves the Predictive Power of Pharmacogenomic Analyses and Helps Identify NADPH as Biomarker for Ferroptosis Sensitivity.

Shimada K, Hayano M, Pagano NC, Stockwell BR. Shimada K, et al. Cell Chem Biol. 2016 Feb 18;23(2):225-235. doi: 10.1016/j.chembiol.2015.11.016. Epub 2016 Feb 4. Cell Chem Biol. 2016. PMID: 26853626 Free PMC article.

7

Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models.

Skouta R, Dixon SJ, Wang J, Dunn DE, Orman M, Shimada K, Rosenberg PA, Lo DC, Weinberg JM, Linkermann A, Stockwell BR. Skouta R, et al. Among authors: shimada k. J Am Chem Soc. 2014 Mar 26;136(12):4551-6. doi: 10.1021/ja411006a. Epub 2014 Mar 14. J Am Chem Soc. 2014. PMID: 24592866 Free PMC article.

8

Unraveling the mechanism of cell death induced by chemical fibrils.

Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. Julien O, et al. Among authors: shimada k. Nat Chem Biol. 2014 Nov;10(11):969-76. doi: 10.1038/nchembio.1639. Epub 2014 Sep 28. Nat Chem Biol. 2014. PMID: 25262416 Free PMC article.

9

Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency.

Yang WS, Shimada K, Delva D, Patel M, Ode E, Skouta R, Stockwell BR. Yang WS, et al. Among authors: shimada k. ACS Med Chem Lett. 2012 Jan 12;3(1):35-38. doi: 10.1021/ml200195s. Epub 2011 Oct 31. ACS Med Chem Lett. 2012. PMID: 22247791 Free PMC article.

10

Development of small-molecule probes that selectively kill cells induced to express mutant RAS.

Weïwer M, Bittker JA, Lewis TA, Shimada K, Yang WS, MacPherson L, Dandapani S, Palmer M, Stockwell BR, Schreiber SL, Munoz B. Weïwer M, et al. Among authors: shimada k. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6. doi: 10.1016/j.bmcl.2011.09.047. Epub 2011 Sep 28. Bioorg Med Chem Lett. 2012. PMID: 22297109 Free PMC article.

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