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Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia.
Brabson JP, Leesang T, Yap YS, Wang J, Lam MQ, Fang B, Dolgalev I, Barbieri DA, Strippoli V, Bañuelos CP, Mohammad S, Lyon P, Chaudhry S, Donich D, Swirski A, Roberts E, Diaz I, Karl D, Dos Santos HG, Shiekhattar R, Neel BG, Nimer SD, Verdun RE, Bilbao D, Figueroa ME, Cimmino L. Brabson JP, et al. Among authors: shiekhattar r. Cell Rep. 2023 Jan 31;42(1):112027. doi: 10.1016/j.celrep.2023.112027. Epub 2023 Jan 23. Cell Rep. 2023. PMID: 36848231 Free PMC article.
PRAME induces genomic instability in uveal melanoma.
Kurtenbach S, Sanchez MI, Kuznetsoff J, Rodriguez DA, Weich N, Dollar JJ, Cruz A, Kurtenbach S, Field MG, Durante MA, Decatur C, Sorouri M, Lai F, Yenisehirli G, Fang B, Shiekhattar R, Pelaez D, Correa ZM, Verdun RE, Harbour JW. Kurtenbach S, et al. Among authors: shiekhattar r. Oncogene. 2024 Feb;43(8):555-565. doi: 10.1038/s41388-023-02887-0. Epub 2023 Nov 29. Oncogene. 2024. PMID: 38030788 Free PMC article.
The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression.
Mas G, Man N, Nakata Y, Martinez-Caja C, Karl D, Beckedorff F, Tamiro F, Chen C, Duffort S, Itonaga H, Mookhtiar AK, Kunkalla K, Valencia AM, Collings CK, Kadoch C, Vega F, Kogan SC, Shiekhattar R, Morey L, Bilbao D, Nimer SD. Mas G, et al. Among authors: shiekhattar r. J Clin Invest. 2023 Jul 3;133(13):e158419. doi: 10.1172/JCI158419. J Clin Invest. 2023. PMID: 37200093 Free PMC article.
PRAME induces genomic instability in uveal melanoma.
Kurtenbach S, Sanchez MI, Kuznetsoff J, Rodriguez DA, Weich N, Dollar J, Cruz A, Kurtenbach S, Field MG, Durante MA, Decatur C, Sorouri M, Lai F, Shiekhattar R, Pelaez D, Correa ZM, Verdun RE, Harbour JW. Kurtenbach S, et al. Among authors: shiekhattar r. Res Sq [Preprint]. 2023 Apr 26:rs.3.rs-2861359. doi: 10.21203/rs.3.rs-2861359/v1. Res Sq. 2023. PMID: 37162820 Free PMC article. Updated. Preprint.
The Integrator complex regulates microRNA abundance through RISC loading.
Kirstein N, Dokaneheifard S, Cingaram PR, Valencia MG, Beckedorff F, Gomes Dos Santos H, Blumenthal E, Tayari MM, Gaidosh GS, Shiekhattar R. Kirstein N, et al. Among authors: shiekhattar r. Sci Adv. 2023 Feb 10;9(6):eadf0597. doi: 10.1126/sciadv.adf0597. Epub 2023 Feb 10. Sci Adv. 2023. PMID: 36763664 Free PMC article.
Dietary palmitic acid promotes a prometastatic memory via Schwann cells.
Pascual G, Domínguez D, Elosúa-Bayes M, Beckedorff F, Laudanna C, Bigas C, Douillet D, Greco C, Symeonidi A, Hernández I, Gil SR, Prats N, Bescós C, Shiekhattar R, Amit M, Heyn H, Shilatifard A, Benitah SA. Pascual G, et al. Among authors: shiekhattar r. Nature. 2021 Nov;599(7885):485-490. doi: 10.1038/s41586-021-04075-0. Epub 2021 Nov 10. Nature. 2021. PMID: 34759321 Free article.
Integrator enforces the fidelity of transcriptional termination at protein-coding genes.
Dasilva LF, Blumenthal E, Beckedorff F, Cingaram PR, Gomes Dos Santos H, Edupuganti RR, Zhang A, Dokaneheifard S, Aoi Y, Yue J, Kirstein N, Tayari MM, Shilatifard A, Shiekhattar R. Dasilva LF, et al. Among authors: shiekhattar r. Sci Adv. 2021 Nov 5;7(45):eabe3393. doi: 10.1126/sciadv.abe3393. Epub 2021 Nov 3. Sci Adv. 2021. PMID: 34730992 Free PMC article.
133 results