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Imidazoline- and Benzamidine-Based Trypanosome Alternative Oxidase Inhibitors: Synthesis and Structure-Activity Relationship Studies.
Cisneros D, Cueto-Díaz EJ, Medina-Gil T, Chevillard R, Bernal-Fraile T, López-Sastre R, Aldfer MM, Ungogo MA, Elati HAA, Arai N, Otani M, Matsushiro S, Kojima C, Ebiloma GU, Shiba T, de Koning HP, Dardonville C. Cisneros D, et al. Among authors: shiba t. ACS Med Chem Lett. 2022 Jan 28;13(2):312-318. doi: 10.1021/acsmedchemlett.1c00717. eCollection 2022 Feb 10. ACS Med Chem Lett. 2022. PMID: 35178188 Free PMC article.
Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense.
Ebiloma GU, Ayuga TD, Balogun EO, Gil LA, Donachie A, Kaiser M, Herraiz T, Inaoka DK, Shiba T, Harada S, Kita K, de Koning HP, Dardonville C. Ebiloma GU, et al. Among authors: shiba t. Eur J Med Chem. 2018 Apr 25;150:385-402. doi: 10.1016/j.ejmech.2018.02.075. Epub 2018 Feb 26. Eur J Med Chem. 2018. PMID: 29544150 Free article.
SAR of 4-Alkoxybenzoic Acid Inhibitors of the Trypanosome Alternative Oxidase.
Meco-Navas A, Ebiloma GU, Martín-Domínguez A, Martínez-Benayas I, Cueto-Díaz EJ, Alhejely AS, Balogun EO, Saito M, Matsui M, Arai N, Shiba T, Harada S, de Koning HP, Dardonville C. Meco-Navas A, et al. Among authors: shiba t. ACS Med Chem Lett. 2018 Jul 31;9(9):923-928. doi: 10.1021/acsmedchemlett.8b00282. eCollection 2018 Sep 13. ACS Med Chem Lett. 2018. PMID: 30258542 Free PMC article.
Synthesis, biological, and photophysical studies of molecular rotor-based fluorescent inhibitors of the trypanosome alternative oxidase.
Cueto-Díaz EJ, Ebiloma GU, Alfayez IA, Ungogo MA, Lemgruber L, González-García MC, Giron MD, Salto R, Fueyo-González FJ, Shiba T, González-Vera JA, Ruedas Rama MJ, Orte A, de Koning HP, Dardonville C. Cueto-Díaz EJ, et al. Among authors: shiba t. Eur J Med Chem. 2021 Aug 5;220:113470. doi: 10.1016/j.ejmech.2021.113470. Epub 2021 Apr 16. Eur J Med Chem. 2021. PMID: 33940464 Free article.
Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion.
Fueyo González FJ, Ebiloma GU, Izquierdo García C, Bruggeman V, Sánchez Villamañán JM, Donachie A, Balogun EO, Inaoka DK, Shiba T, Harada S, Kita K, de Koning HP, Dardonville C. Fueyo González FJ, et al. Among authors: shiba t. J Med Chem. 2017 Feb 23;60(4):1509-1522. doi: 10.1021/acs.jmedchem.6b01740. Epub 2017 Feb 9. J Med Chem. 2017. PMID: 28112515 Free article.
Structure of the trypanosome cyanide-insensitive alternative oxidase.
Shiba T, Kido Y, Sakamoto K, Inaoka DK, Tsuge C, Tatsumi R, Takahashi G, Balogun EO, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Saimoto H, Moore AL, Harada S, Kita K. Shiba T, et al. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4580-5. doi: 10.1073/pnas.1218386110. Epub 2013 Mar 4. Proc Natl Acad Sci U S A. 2013. PMID: 23487766 Free PMC article.
Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei.
Balogun EO, Inaoka DK, Shiba T, Tsuge C, May B, Sato T, Kido Y, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Michels PAM, Watanabe YI, Moore AL, Harada S, Kita K. Balogun EO, et al. Among authors: shiba t. FASEB J. 2019 Nov;33(11):13002-13013. doi: 10.1096/fj.201901342R. Epub 2019 Sep 16. FASEB J. 2019. PMID: 31525300
Although the EC(50) of compound 17b against trypanosome cells was 1.77 M, it had no effect on cultured human cells, even at 50 M.-Balogun, E. O., Inaoka, D. K., Shiba, T., Tsuge, C., May, B., Sato, T., Kido, Y., Nara, T., Aoki, T., Honma, T …
Although the EC(50) of compound 17b against trypanosome cells was 1.77 M, it had no effect on cultured human cells, even at 50 M.-Balogun, E …
Crystallization and preliminary crystallographic analysis of cyanide-insensitive alternative oxidase from Trypanosoma brucei brucei.
Kido Y, Shiba T, Inaoka DK, Sakamoto K, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Moore A, Harada S, Kita K. Kido Y, et al. Among authors: shiba t. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Mar 1;66(Pt 3):275-8. doi: 10.1107/S1744309109054062. Epub 2010 Feb 24. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20208159 Free PMC article.
798 results