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Substrate analog interaction with MCR-1 offers insight into the rising threat of the plasmid-mediated transferable colistin resistance.
Wei P, Song G, Shi M, Zhou Y, Liu Y, Lei J, Chen P, Yin L. Wei P, et al. Among authors: shi m. FASEB J. 2018 Feb;32(2):1085-1098. doi: 10.1096/fj.201700705R. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29079699
These data demonstrate the crucial role of the PEA- and lipid A-binding pockets and provide novel insights into the structure-based mechanisms, important drug-target hot spots, and a drug template for further drug development to combat the urgent, rising threat of MCR-1-mediated …
These data demonstrate the crucial role of the PEA- and lipid A-binding pockets and provide novel insights into the structure-based mechanis …
7,427 results