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Epigenetic scores for the circulating proteome as tools for disease prediction.
Gadd DA, Hillary RF, McCartney DL, Zaghlool SB, Stevenson AJ, Cheng Y, Fawns-Ritchie C, Nangle C, Campbell A, Flaig R, Harris SE, Walker RM, Shi L, Tucker-Drob EM, Gieger C, Peters A, Waldenberger M, Graumann J, McRae AF, Deary IJ, Porteous DJ, Hayward C, Visscher PM, Cox SR, Evans KL, McIntosh AM, Suhre K, Marioni RE. Gadd DA, et al. Among authors: shi l. Elife. 2022 Jan 13;11:e71802. doi: 10.7554/eLife.71802. Elife. 2022. PMID: 35023833 Free PMC article.
Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals.
Shi L, Buchanan CR, Cox SR, Hillary RF, Marioni RE, Campbell A, Hayward C, Stolicyn A, Whalley HC, Harris MA, Waymont J, Waiter G, Backhouse E, Wardlaw JM, Steele D, Mcintosh A, Lovestone S, Buckley NJ, Nevado-Holgado AJ. Shi L, et al. Alzheimers Dement (Amst). 2021 Sep 27;13(1):e12240. doi: 10.1002/dad2.12240. eCollection 2021. Alzheimers Dement (Amst). 2021. PMID: 34604499 Free PMC article.
Genome- and epigenome-wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk.
Hillary RF, Gadd DA, McCartney DL, Shi L, Campbell A, Walker RM, Ritchie CW, Deary IJ, Evans KL, Nevado-Holgado AJ, Hayward C, Porteous DJ, McIntosh AM, Lovestone S, Robinson MR, Marioni RE. Hillary RF, et al. Among authors: shi l. Alzheimers Dement (Amst). 2022 Apr 20;14(1):e12280. doi: 10.1002/dad2.12280. eCollection 2022. Alzheimers Dement (Amst). 2022. PMID: 35475137 Free PMC article.
Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health.
Gadd DA, Hillary RF, McCartney DL, Shi L, Stolicyn A, Robertson NA, Walker RM, McGeachan RI, Campbell A, Xueyi S, Barbu MC, Green C, Morris SW, Harris MA, Backhouse EV, Wardlaw JM, Steele JD, Oyarzún DA, Muniz-Terrera G, Ritchie C, Nevado-Holgado A, Chandra T, Hayward C, Evans KL, Porteous DJ, Cox SR, Whalley HC, McIntosh AM, Marioni RE. Gadd DA, et al. Among authors: shi l. Nat Commun. 2022 Aug 9;13(1):4670. doi: 10.1038/s41467-022-32319-8. Nat Commun. 2022. PMID: 35945220 Free PMC article.
Interplay of Metabolome and Gut Microbiome in Individuals With Major Depressive Disorder vs Control Individuals.
Amin N, Liu J, Bonnechere B, MahmoudianDehkordi S, Arnold M, Batra R, Chiou YJ, Fernandes M, Ikram MA, Kraaij R, Krumsiek J, Newby D, Nho K, Radjabzadeh D, Saykin AJ, Shi L, Sproviero W, Winchester L, Yang Y, Nevado-Holgado AJ, Kastenmüller G, Kaddurah-Daouk R, van Duijn CM. Amin N, et al. Among authors: shi l. JAMA Psychiatry. 2023 Jun 1;80(6):597-609. doi: 10.1001/jamapsychiatry.2023.0685. JAMA Psychiatry. 2023. PMID: 37074710 Free PMC article.
Predicting AT(N) pathologies in Alzheimer's disease from blood-based proteomic data using neural networks.
Zhang Y, Ghose U, Buckley NJ, Engelborghs S, Sleegers K, Frisoni GB, Wallin A, Lleó A, Popp J, Martinez-Lage P, Legido-Quigley C, Barkhof F, Zetterberg H, Visser PJ, Bertram L, Lovestone S, Nevado-Holgado AJ, Shi L. Zhang Y, et al. Among authors: shi l. Front Aging Neurosci. 2022 Nov 29;14:1040001. doi: 10.3389/fnagi.2022.1040001. eCollection 2022. Front Aging Neurosci. 2022. PMID: 36523958 Free PMC article.
Plasma Proteomic Biomarkers Relating to Alzheimer's Disease: A Meta-Analysis Based on Our Own Studies.
Shi L, Buckley NJ, Bos I, Engelborghs S, Sleegers K, Frisoni GB, Wallin A, Lléo A, Popp J, Martinez-Lage P, Legido-Quigley C, Barkhof F, Zetterberg H, Visser PJ, Bertram L, Lovestone S, Nevado-Holgado AJ. Shi L, et al. Front Aging Neurosci. 2021 Jul 21;13:712545. doi: 10.3389/fnagi.2021.712545. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34366831 Free PMC article.
Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life.
Walker KA, Chen J, Shi L, Yang Y, Fornage M, Zhou L, Schlosser P, Surapaneni A, Grams ME, Duggan MR, Peng Z, Gomez GT, Tin A, Hoogeveen RC, Sullivan KJ, Ganz P, Lindbohm JV, Kivimaki M, Nevado-Holgado AJ, Buckley N, Gottesman RF, Mosley TH, Boerwinkle E, Ballantyne CM, Coresh J. Walker KA, et al. Among authors: shi l. Sci Transl Med. 2023 Jul 19;15(705):eadf5681. doi: 10.1126/scitranslmed.adf5681. Epub 2023 Jul 19. Sci Transl Med. 2023. PMID: 37467317
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