Shi L - Search Results

1

Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model.

Hu E, Hong FT, Aral J, Long J, Piper DE, Poppe L, Andrews KL, Hager T, Davis C, Li H, Wong P, Gavva N, Shi L, Zhu DXD, Lehto SG, Xu C, Miranda LP. Hu E, et al. Among authors: shi l. J Med Chem. 2021 Mar 25;64(6):3427-3438. doi: 10.1021/acs.jmedchem.0c01396. Epub 2021 Mar 15. J Med Chem. 2021. PMID: 33715378

2

Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor.

Miranda LP, Holder JR, Shi L, Bennett B, Aral J, Gegg CV, Wright M, Walker K, Doellgast G, Rogers R, Li H, Valladares V, Salyers K, Johnson E, Wild K. Miranda LP, et al. Among authors: shi l. J Med Chem. 2008 Dec 25;51(24):7889-97. doi: 10.1021/jm8009298. J Med Chem. 2008. PMID: 19053766

3

Pharmacologic Characterization of AMG 334, a Potent and Selective Human Monoclonal Antibody against the Calcitonin Gene-Related Peptide Receptor.

Shi L, Lehto SG, Zhu DX, Sun H, Zhang J, Smith BP, Immke DC, Wild KD, Xu C. Shi L, et al. J Pharmacol Exp Ther. 2016 Jan;356(1):223-31. doi: 10.1124/jpet.115.227793. Epub 2015 Nov 11. J Pharmacol Exp Ther. 2016. PMID: 26559125

4

PAC1 receptor blockade reduces central nociceptive activity: new approach for primary headache?

Hoffmann J, Miller S, Martins-Oliveira M, Akerman S, Supronsinchai W, Sun H, Shi L, Wang J, Zhu D, Lehto S, Liu H, Yin R, Moyer BD, Xu C, Goadsby PJ. Hoffmann J, et al. Among authors: shi l. Pain. 2020 Jul;161(7):1670-1681. doi: 10.1097/j.pain.0000000000001858. Pain. 2020. PMID: 32142016 Free PMC article.

5

Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade.

Gavva NR, Bannon AW, Hovland DN Jr, Lehto SG, Klionsky L, Surapaneni S, Immke DC, Henley C, Arik L, Bak A, Davis J, Ernst N, Hever G, Kuang R, Shi L, Tamir R, Wang J, Wang W, Zajic G, Zhu D, Norman MH, Louis JC, Magal E, Treanor JJ. Gavva NR, et al. Among authors: shi l. J Pharmacol Exp Ther. 2007 Oct;323(1):128-37. doi: 10.1124/jpet.107.125674. Epub 2007 Jul 25. J Pharmacol Exp Ther. 2007. PMID: 17652633

6

Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V.

Moyer BD, Murray JK, Ligutti J, Andrews K, Favreau P, Jordan JB, Lee JH, Liu D, Long J, Sham K, Shi L, Stöcklin R, Wu B, Yin R, Yu V, Zou A, Biswas K, Miranda LP. Moyer BD, et al. Among authors: shi l. PLoS One. 2018 May 3;13(5):e0196791. doi: 10.1371/journal.pone.0196791. eCollection 2018. PLoS One. 2018. PMID: 29723257 Free PMC article.

7

Peptide antagonists of the calcitonin gene-related peptide (CGRP) receptor with improved pharmacokinetics and pharmacodynamics.

Miranda LP, Shi L, Holder JR, Wright M, Gegg CV, Johnson E, Wild K, Stenkilsson M, Doellgast G, Manning BH, Salyers K. Miranda LP, et al. Among authors: shi l. Biopolymers. 2013 Jul;100(4):422-30. doi: 10.1002/bip.22270. Biopolymers. 2013. PMID: 23868210

8

Molecular determinants of vanilloid sensitivity in TRPV1.

Gavva NR, Klionsky L, Qu Y, Shi L, Tamir R, Edenson S, Zhang TJ, Viswanadhan VN, Toth A, Pearce LV, Vanderah TW, Porreca F, Blumberg PM, Lile J, Sun Y, Wild K, Louis JC, Treanor JJ. Gavva NR, et al. Among authors: shi l. J Biol Chem. 2004 May 7;279(19):20283-95. doi: 10.1074/jbc.M312577200. Epub 2004 Mar 2. J Biol Chem. 2004. PMID: 14996838 Free article.

9

Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies.

Miller S, Liu H, Warfvinge K, Shi L, Dovlatyan M, Xu C, Edvinsson L. Miller S, et al. Among authors: shi l. Neuroscience. 2016 Jul 22;328:165-83. doi: 10.1016/j.neuroscience.2016.04.046. Epub 2016 May 4. Neuroscience. 2016. PMID: 27155150

10

Discovery of the Migraine Prevention Therapeutic Aimovig (Erenumab), the First FDA-Approved Antibody against a G-Protein-Coupled Receptor.

King CT, Gegg CV, Hu SN, Sen Lu H, Chan BM, Berry KA, Brankow DW, Boone TJ, Kezunovic N, Kelley MR, Shi L, Xu C. King CT, et al. Among authors: shi l. ACS Pharmacol Transl Sci. 2019 Sep 3;2(6):485-490. doi: 10.1021/acsptsci.9b00061. eCollection 2019 Dec 13. ACS Pharmacol Transl Sci. 2019. PMID: 32259079 Free PMC article.

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