Sheppard D - Search Results

1

Obesity alters pathology and treatment response in inflammatory disease.

Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ, Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, Cohen JN, Sturgill JL, Crotty Alexander LE, Suh JM, Liddle C, Atkins AR, Yu RT, Downes M, Liu S, Nikolajczyk BS, Lee IK, Guttman-Yassky E, Ansel KM, Woodruff PG, Fahy JV, Sheppard D, Gallo RL, Ye CJ, Evans RM, Zheng Y, Marson A. Bapat SP, et al. Among authors: sheppard d. Nature. 2022 Apr;604(7905):337-342. doi: 10.1038/s41586-022-04536-0. Epub 2022 Mar 30. Nature. 2022. PMID: 35355021 Free PMC article.

2

Expression of the human integrin beta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in beta6 knockout mice.

Huang X, Wu J, Zhu W, Pytela R, Sheppard D. Huang X, et al. Among authors: sheppard d. Am J Respir Cell Mol Biol. 1998 Oct;19(4):636-42. doi: 10.1165/ajrcmb.19.4.3293. Am J Respir Cell Mol Biol. 1998. PMID: 9761761

3

Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma.

Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ. Kuperman DA, et al. Among authors: sheppard d. Nat Med. 2002 Aug;8(8):885-9. doi: 10.1038/nm734. Epub 2002 Jul 1. Nat Med. 2002. PMID: 12091879

4

Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice.

Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D. Travis MA, et al. Among authors: sheppard d. Nature. 2007 Sep 20;449(7160):361-5. doi: 10.1038/nature06110. Epub 2007 Aug 12. Nature. 2007. PMID: 17694047 Free PMC article.

5

The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.

Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D. Sugimoto K, et al. Among authors: sheppard d. J Clin Invest. 2012 Feb;122(2):748-58. doi: 10.1172/JCI58815. Epub 2012 Jan 9. J Clin Invest. 2012. PMID: 22232213 Free PMC article.

6

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.

Kudo M, Melton AC, Chen C, Engler MB, Huang KE, Ren X, Wang Y, Bernstein X, Li JT, Atabai K, Huang X, Sheppard D. Kudo M, et al. Among authors: sheppard d. Nat Med. 2012 Mar 4;18(4):547-54. doi: 10.1038/nm.2684. Nat Med. 2012. PMID: 22388091 Free PMC article.

7

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.

Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR. Huang F, et al. Among authors: sheppard d. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16354-9. doi: 10.1073/pnas.1214596109. Epub 2012 Sep 17. Proc Natl Acad Sci U S A. 2012. PMID: 22988107 Free PMC article.

8

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.

Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. Henderson NC, et al. Among authors: sheppard d. Nat Med. 2013 Dec;19(12):1617-24. doi: 10.1038/nm.3282. Epub 2013 Nov 10. Nat Med. 2013. PMID: 24216753 Free PMC article.

9

Transforming growth factor-β plays divergent roles in modulating vascular remodeling, inflammation, and pulmonary fibrosis in a murine model of scleroderma.

Tsujino K, Reed NI, Atakilit A, Ren X, Sheppard D. Tsujino K, et al. Among authors: sheppard d. Am J Physiol Lung Cell Mol Physiol. 2017 Jan 1;312(1):L22-L31. doi: 10.1152/ajplung.00428.2016. Epub 2016 Nov 18. Am J Physiol Lung Cell Mol Physiol. 2017. PMID: 27864286 Free PMC article.

10

Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice.

Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD Jr, Prakash YS, Bhattacharya M. Fong V, et al. Among authors: sheppard d. JCI Insight. 2018 Nov 2;3(21):e123578. doi: 10.1172/jci.insight.123578. JCI Insight. 2018. PMID: 30385725 Free PMC article.

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