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Clofazimine broadly inhibits coronaviruses including SARS-CoV-2.
Yuan S, Yin X, Meng X, Chan JF, Ye ZW, Riva L, Pache L, Chan CC, Lai PM, Chan CC, Poon VK, Lee AC, Matsunaga N, Pu Y, Yuen CK, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Lau CY, Sit KY, Au WK, Wang R, Zhang YY, Tang YD, Clausen TM, Pihl J, Oh J, Sze KH, Zhang AJ, Chu H, Kok KH, Wang D, Cai XH, Esko JD, Hung IF, Li RA, Chen H, Sun H, Jin DY, Sun R, Chanda SK, Yuen KY. Yuan S, et al. Among authors: sheng l. Nature. 2021 May;593(7859):418-423. doi: 10.1038/s41586-021-03431-4. Epub 2021 Mar 16. Nature. 2021. PMID: 33727703
Clofazimine is a broad-spectrum coronavirus inhibitor that antagonizes SARS-CoV-2 replication in primary human cell culture and hamsters.
Yuan S, Yin X, Meng X, Chan J, Ye ZW, Riva L, Pache L, Chan CC, Lai PM, Chan C, Poon V, Matsunaga N, Pu Y, Yuen CK, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Sze KH, Zhang J, Chu H, Kok KH, To K, Jin DY, Sun R, Chanda S, Yuen KY. Yuan S, et al. Among authors: sheng l. Res Sq [Preprint]. 2020 Oct 7:rs.3.rs-86169. doi: 10.21203/rs.3.rs-86169/v1. Res Sq. 2020. PMID: 33052331 Free PMC article. Updated. Preprint.
Martynoside rescues 5-fluorouracil-impaired ribosome biogenesis by stabilizing RPL27A.
Hong M, Du Y, Chen D, Shi Y, Hu M, Tang K, Hong Z, Meng X, Xu W, Wu G, Yao Y, Chen L, Chen W, Lau CY, Sheng L, Zhang TH, Huang H, Fang Z, Shen Y, Sun F, Qian J, Qu H, Zheng S, Zhang S, Ding K, Sun R. Hong M, et al. Among authors: sheng l. Sci Bull (Beijing). 2023 Aug 15;68(15):1662-1677. doi: 10.1016/j.scib.2023.07.018. Epub 2023 Jul 15. Sci Bull (Beijing). 2023. PMID: 37481436 Free article.
2,022 results