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Slow Off-Rate Modified Aptamer (SOMAmer) Proteomic Analysis of Patient-Derived Malignant Glioma Identifies Distinct Cellular Proteomes.
Thanasupawat T, Glogowska A, Pascoe C, Krishnan SN, Munir M, Begum F, Beiko J, Krcek J, Del Bigio MR, Pitz M, Shen Y, Spicer V, Coombs KM, Wilkins J, Hombach-Klonisch S, Klonisch T. Thanasupawat T, et al. Among authors: shen y. Int J Mol Sci. 2021 Sep 3;22(17):9566. doi: 10.3390/ijms22179566. Int J Mol Sci. 2021. PMID: 34502484 Free PMC article.
Comprehensive genomic profiling of glioblastoma tumors, BTICs, and xenografts reveals stability and adaptation to growth environments.
Shen Y, Grisdale CJ, Islam SA, Bose P, Lever J, Zhao EY, Grinshtein N, Ma Y, Mungall AJ, Moore RA, Lun X, Senger DL, Robbins SM, Wang AY, MacIsaac JL, Kobor MS, Luchman HA, Weiss S, Chan JA, Blough MD, Kaplan DR, Cairncross JG, Marra MA, Jones SJM. Shen Y, et al. Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):19098-19108. doi: 10.1073/pnas.1813495116. Epub 2019 Aug 30. Proc Natl Acad Sci U S A. 2019. PMID: 31471491 Free PMC article.
Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression.
De Boeck A, Ahn BY, D'Mello C, Lun X, Menon SV, Alshehri MM, Szulzewsky F, Shen Y, Khan L, Dang NH, Reichardt E, Goring KA, King J, Grisdale CJ, Grinshtein N, Hambardzumyan D, Reilly KM, Blough MD, Cairncross JG, Yong VW, Marra MA, Jones SJM, Kaplan DR, McCoy KD, Holland EC, Bose P, Chan JA, Robbins SM, Senger DL. De Boeck A, et al. Among authors: shen y. Nat Commun. 2020 Oct 5;11(1):4997. doi: 10.1038/s41467-020-18569-4. Nat Commun. 2020. PMID: 33020472 Free PMC article.
Pan-cancer analysis of advanced patient tumors reveals interactions between therapy and genomic landscapes.
Pleasance E, Titmuss E, Williamson L, Kwan H, Culibrk L, Zhao EY, Dixon K, Fan K, Bowlby R, Jones MR, Shen Y, Grewal JK, Ashkani J, Wee K, Grisdale CJ, Thibodeau ML, Bozoky Z, Pearson H, Majounie E, Vira T, Shenwai R, Mungall KL, Chuah E, Davies A, Warren M, Reisle C, Bonakdar M, Taylor GA, Csizmok V, Chan SK, Zong Z, Bilobram S, Muhammadzadeh A, D'Souza D, Corbett RD, MacMillan D, Carreira M, Choo C, Bleile D, Sadeghi S, Zhang W, Wong T, Cheng D, Brown SD, Holt RA, Moore RA, Mungall AJ, Zhao Y, Nelson J, Fok A, Ma Y, Lee MKC, Lavoie JM, Mendis S, Karasinska JM, Deol B, Fisic A, Schaeffer DF, Yip S, Schrader K, Regier DA, Weymann D, Chia S, Gelmon K, Tinker A, Sun S, Lim H, Renouf DJ, Laskin J, Jones SJM, Marra MA. Pleasance E, et al. Among authors: shen y. Nat Cancer. 2020 Apr;1(4):452-468. doi: 10.1038/s43018-020-0050-6. Epub 2020 Apr 13. Nat Cancer. 2020. PMID: 35121966
Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1.
Mazor T, Chesnelong C, Pankov A, Jalbert LE, Hong C, Hayes J, Smirnov IV, Marshall R, Souza CF, Shen Y, Viswanath P, Noushmehr H, Ronen SM, Jones SJM, Marra MA, Cairncross JG, Perry A, Nelson SJ, Chang SM, Bollen AW, Molinaro AM, Bengtsson H, Olshen AB, Weiss S, Phillips JJ, Luchman HA, Costello JF. Mazor T, et al. Among authors: shen y. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10743-10748. doi: 10.1073/pnas.1708914114. Epub 2017 Sep 15. Proc Natl Acad Sci U S A. 2017. PMID: 28916733 Free PMC article.
ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts.
Yuan AL, Ricks CB, Bohm AK, Lun X, Maxwell L, Safdar S, Bukhari S, Gerber A, Sayeed W, Bering EA, Pedersen H, Chan JA, Shen Y, Marra M, Kaplan DR, Mason W, Goodman LD, Ezhilarasan R, Kaufmann AB, Cabral M, Robbins SM, Senger DL, Cahill DP, Sulman EP, Cairncross JG, Blough MD. Yuan AL, et al. Among authors: shen y. PLoS One. 2018 Aug 28;13(8):e0202860. doi: 10.1371/journal.pone.0202860. eCollection 2018. PLoS One. 2018. PMID: 30153289 Free PMC article.
The impact of whole genome and transcriptome analysis (WGTA) on predictive biomarker discovery and diagnostic accuracy of advanced malignancies.
Tessier-Cloutier B, Grewal JK, Jones MR, Pleasance E, Shen Y, Cai E, Dunham C, Hoang L, Horst B, Huntsman DG, Ionescu D, Karnezis AN, Lee AF, Lee CH, Lee TH, Twa DD, Mungall AJ, Mungall K, Naso JR, Ng T, Schaeffer DF, Sheffield BS, Skinnider B, Smith T, Williamson L, Zhong E, Regier DA, Laskin J, Marra MA, Gilks CB, Jones SJ, Yip S. Tessier-Cloutier B, et al. Among authors: shen y. J Pathol Clin Res. 2022 Jul;8(4):395-407. doi: 10.1002/cjp2.265. Epub 2022 Mar 8. J Pathol Clin Res. 2022. PMID: 35257510 Free PMC article.
macroH2A2 antagonizes epigenetic programs of stemness in glioblastoma.
Nikolic A, Maule F, Bobyn A, Ellestad K, Paik S, Marhon SA, Mehdipour P, Lun X, Chen HM, Mallard C, Hay AJ, Johnston MJ, Gafuik CJ, Zemp FJ, Shen Y, Ninkovic N, Osz K, Labit E, Berger ND, Brownsey DK, Kelly JJ, Biernaskie J, Dirks PB, Derksen DJ, Jones SJM, Senger DL, Chan JA, Mahoney DJ, De Carvalho DD, Gallo M. Nikolic A, et al. Among authors: shen y. Nat Commun. 2023 May 27;14(1):3062. doi: 10.1038/s41467-023-38919-2. Nat Commun. 2023. PMID: 37244935 Free PMC article.
In vitro modeling of glioblastoma initiation using PDGF-AA and p53-null neural progenitors.
Bohm AK, DePetro J, Binding CE, Gerber A, Chahley N, Berger ND, Ware M, Thomas K, Senapathi U, Bukhari S, Chen C, Chahley E, Grisdale C, Lawn S, Yu Y, Wong R, Shen Y, Omairi H, Mirzaei R, Alshatti N, Pedersen H, Yong W, Weiss S, Chan J, Cimino PJ, Kelly J, Jones S, Holland E, Blough M, Cairncross G. Bohm AK, et al. Among authors: shen y. Neuro Oncol. 2020 Aug 17;22(8):1150-1161. doi: 10.1093/neuonc/noaa093. Neuro Oncol. 2020. PMID: 32296841 Free PMC article.
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