Shen W - Search Results

1

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index.

Shen W, De Hoyos CL, Migawa MT, Vickers TA, Sun H, Low A, Bell TA 3rd, Rahdar M, Mukhopadhyay S, Hart CE, Bell M, Riney S, Murray SF, Greenlee S, Crooke RM, Liang XH, Seth PP, Crooke ST. Shen W, et al. Nat Biotechnol. 2019 Jun;37(6):640-650. doi: 10.1038/s41587-019-0106-2. Epub 2019 Apr 29. Nat Biotechnol. 2019. PMID: 31036929

2

Phosphorothioate oligonucleotides can displace NEAT1 RNA and form nuclear paraspeckle-like structures.

Shen W, Liang XH, Crooke ST. Shen W, et al. Nucleic Acids Res. 2014 Jul;42(13):8648-62. doi: 10.1093/nar/gku579. Epub 2014 Jul 10. Nucleic Acids Res. 2014. PMID: 25013176 Free PMC article.

3

Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2'-modifications and enhances antisense activity.

Liang XH, Shen W, Sun H, Kinberger GA, Prakash TP, Nichols JG, Crooke ST. Liang XH, et al. Among authors: shen w. Nucleic Acids Res. 2016 May 5;44(8):3892-907. doi: 10.1093/nar/gkw144. Epub 2016 Mar 3. Nucleic Acids Res. 2016. PMID: 26945041 Free PMC article.

4

Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames.

Liang XH, Shen W, Sun H, Migawa MT, Vickers TA, Crooke ST. Liang XH, et al. Among authors: shen w. Nat Biotechnol. 2016 Aug;34(8):875-80. doi: 10.1038/nbt.3589. Epub 2016 Jul 11. Nat Biotechnol. 2016. PMID: 27398791

5

Cellular uptake and trafficking of antisense oligonucleotides.

Crooke ST, Wang S, Vickers TA, Shen W, Liang XH. Crooke ST, et al. Among authors: shen w. Nat Biotechnol. 2017 Mar;35(3):230-237. doi: 10.1038/nbt.3779. Epub 2017 Feb 27. Nat Biotechnol. 2017. PMID: 28244996 Review.

6

Antisense oligonucleotides targeting translation inhibitory elements in 5' UTRs can selectively increase protein levels.

Liang XH, Sun H, Shen W, Wang S, Yao J, Migawa MT, Bui HH, Damle SS, Riney S, Graham MJ, Crooke RM, Crooke ST. Liang XH, et al. Among authors: shen w. Nucleic Acids Res. 2017 Sep 19;45(16):9528-9546. doi: 10.1093/nar/gkx632. Nucleic Acids Res. 2017. PMID: 28934489 Free PMC article.

7

Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides.

Bailey JK, Shen W, Liang XH, Crooke ST. Bailey JK, et al. Among authors: shen w. Nucleic Acids Res. 2017 Oct 13;45(18):10649-10671. doi: 10.1093/nar/gkx709. Nucleic Acids Res. 2017. PMID: 28977508 Free PMC article.

8

Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins.

Shen W, De Hoyos CL, Sun H, Vickers TA, Liang XH, Crooke ST. Shen W, et al. Nucleic Acids Res. 2018 Mar 16;46(5):2204-2217. doi: 10.1093/nar/gky060. Nucleic Acids Res. 2018. PMID: 29390093 Free PMC article.

9

COPII vesicles can affect the activity of antisense oligonucleotides by facilitating the release of oligonucleotides from endocytic pathways.

Liang XH, Sun H, Nichols JG, Allen N, Wang S, Vickers TA, Shen W, Hsu CW, Crooke ST. Liang XH, et al. Among authors: shen w. Nucleic Acids Res. 2018 Nov 2;46(19):10225-10245. doi: 10.1093/nar/gky841. Nucleic Acids Res. 2018. PMID: 30239896 Free PMC article.

10

Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins.

Migawa MT, Shen W, Wan WB, Vasquez G, Oestergaard ME, Low A, De Hoyos CL, Gupta R, Murray S, Tanowitz M, Bell M, Nichols JG, Gaus H, Liang XH, Swayze EE, Crooke ST, Seth PP. Migawa MT, et al. Among authors: shen w. Nucleic Acids Res. 2019 Jun 20;47(11):5465-5479. doi: 10.1093/nar/gkz247. Nucleic Acids Res. 2019. PMID: 31034558 Free PMC article.

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