Shen S - Search Results

1

Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model.

Shen S, Picci C, Ustinova K, Benoy V, Kutil Z, Zhang G, Tavares MT, Pavlíček J, Zimprich CA, Robers MB, Van Den Bosch L, Bařinka C, Langley B, Kozikowski AP. Shen S, et al. J Med Chem. 2021 Apr 22;64(8):4810-4840. doi: 10.1021/acs.jmedchem.0c02210. Epub 2021 Apr 8. J Med Chem. 2021. PMID: 33830764

2

Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease.

Shen S, Benoy V, Bergman JA, Kalin JH, Frojuello M, Vistoli G, Haeck W, Van Den Bosch L, Kozikowski AP. Shen S, et al. ACS Chem Neurosci. 2016 Feb 17;7(2):240-58. doi: 10.1021/acschemneuro.5b00286. Epub 2015 Dec 7. ACS Chem Neurosci. 2016. PMID: 26599234 Free PMC article.

3

Why Hydroxamates May Not Be the Best Histone Deacetylase Inhibitors--What Some May Have Forgotten or Would Rather Forget?

Shen S, Kozikowski AP. Shen S, et al. ChemMedChem. 2016 Jan 5;11(1):15-21. doi: 10.1002/cmdc.201500486. Epub 2015 Nov 25. ChemMedChem. 2016. PMID: 26603496 Free PMC article.

4

Synthesis and Pharmacological Evaluation of Selective Histone Deacetylase 6 Inhibitors in Melanoma Models.

Tavares MT, Shen S, Knox T, Hadley M, Kutil Z, Bařinka C, Villagra A, Kozikowski AP. Tavares MT, et al. Among authors: shen s. ACS Med Chem Lett. 2017 Sep 5;8(10):1031-1036. doi: 10.1021/acsmedchemlett.7b00223. eCollection 2017 Oct 12. ACS Med Chem Lett. 2017. PMID: 29057046 Free PMC article.

5

Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome.

Kozikowski AP, Shen S, Pardo M, Tavares MT, Szarics D, Benoy V, Zimprich CA, Kutil Z, Zhang G, Bařinka C, Robers MB, Van Den Bosch L, Eubanks JH, Jope RS. Kozikowski AP, et al. Among authors: shen s. ACS Chem Neurosci. 2019 Mar 20;10(3):1679-1695. doi: 10.1021/acschemneuro.8b00600. Epub 2018 Dec 14. ACS Chem Neurosci. 2019. PMID: 30511829 Free PMC article.

6

Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models.

Shen S, Hadley M, Ustinova K, Pavlicek J, Knox T, Noonepalle S, Tavares MT, Zimprich CA, Zhang G, Robers MB, Bařinka C, Kozikowski AP, Villagra A. Shen S, et al. J Med Chem. 2019 Sep 26;62(18):8557-8577. doi: 10.1021/acs.jmedchem.9b00946. Epub 2019 Sep 4. J Med Chem. 2019. PMID: 31414801

7

Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models.

Noonepalle S, Shen S, Ptáček J, Tavares MT, Zhang G, Stránský J, Pavlíček J, Ferreira GM, Hadley M, Pelaez G, Bařinka C, Kozikowski AP, Villagra A. Noonepalle S, et al. Among authors: shen s. J Med Chem. 2020 Sep 24;63(18):10246-10262. doi: 10.1021/acs.jmedchem.0c00567. Epub 2020 Sep 2. J Med Chem. 2020. PMID: 32815366

8

Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor.

Porter NJ, Shen S, Barinka C, Kozikowski AP, Christianson DW. Porter NJ, et al. Among authors: shen s. ACS Med Chem Lett. 2018 Nov 21;9(12):1301-1305. doi: 10.1021/acsmedchemlett.8b00487. eCollection 2018 Dec 13. ACS Med Chem Lett. 2018. PMID: 30613344 Free PMC article.

9

HDAC6 inhibition promotes α-tubulin acetylation and ameliorates CMT2A peripheral neuropathy in mice.

Picci C, Wong VSC, Costa CJ, McKinnon MC, Goldberg DC, Swift M, Alam NM, Prusky GT, Shen S, Kozikowski AP, Willis DE, Langley B. Picci C, et al. Among authors: shen s. Exp Neurol. 2020 Jun;328:113281. doi: 10.1016/j.expneurol.2020.113281. Epub 2020 Mar 5. Exp Neurol. 2020. PMID: 32147437

10

Structural and in Vivo Characterization of Tubastatin A, a Widely Used Histone Deacetylase 6 Inhibitor.

Shen S, Svoboda M, Zhang G, Cavasin MA, Motlova L, McKinsey TA, Eubanks JH, Bařinka C, Kozikowski AP. Shen S, et al. ACS Med Chem Lett. 2020 Jan 15;11(5):706-712. doi: 10.1021/acsmedchemlett.9b00560. eCollection 2020 May 14. ACS Med Chem Lett. 2020. PMID: 32435374 Free PMC article.

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