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TLR7 gain-of-function genetic variation causes human lupus.
Brown GJ, Cañete PF, Wang H, Medhavy A, Bones J, Roco JA, He Y, Qin Y, Cappello J, Ellyard JI, Bassett K, Shen Q, Burgio G, Zhang Y, Turnbull C, Meng X, Wu P, Cho E, Miosge LA, Andrews TD, Field MA, Tvorogov D, Lopez AF, Babon JJ, López CA, Gónzalez-Murillo Á, Garulo DC, Pascual V, Levy T, Mallack EJ, Calame DG, Lotze T, Lupski JR, Ding H, Ullah TR, Walters GD, Koina ME, Cook MC, Shen N, de Lucas Collantes C, Corry B, Gantier MP, Athanasopoulos V, Vinuesa CG. Brown GJ, et al. Among authors: shen q, shen n. Nature. 2022 May;605(7909):349-356. doi: 10.1038/s41586-022-04642-z. Epub 2022 Apr 27. Nature. 2022. PMID: 35477763 Free PMC article.
Class-Switch Recombination Occurs Infrequently in Germinal Centers.
Roco JA, Mesin L, Binder SC, Nefzger C, Gonzalez-Figueroa P, Canete PF, Ellyard J, Shen Q, Robert PA, Cappello J, Vohra H, Zhang Y, Nowosad CR, Schiepers A, Corcoran LM, Toellner KM, Polo JM, Meyer-Hermann M, Victora GD, Vinuesa CG. Roco JA, et al. Among authors: shen q. Immunity. 2019 Aug 20;51(2):337-350.e7. doi: 10.1016/j.immuni.2019.07.001. Epub 2019 Jul 30. Immunity. 2019. PMID: 31375460 Free PMC article.
P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.
He Y, Gallman AE, Xie C, Shen Q, Ma J, Wolfreys FD, Sandy M, Arsov T, Wu X, Qin Y, Zhang P, Jiang S, Stanley M, Wu P, Tan J, Ding H, Xue H, Chen W, Xu J, Criswell LA, Nititham J, Adamski M, Kitching AR, Cook MC, Cao L, Shen N, Cyster JG, Vinuesa CG. He Y, et al. Among authors: shen q, shen n. J Exp Med. 2022 Jan 3;219(1):e20211004. doi: 10.1084/jem.20211004. Epub 2021 Dec 10. J Exp Med. 2022. PMID: 34889940 Free PMC article.
De Novo PACSIN1 Gene Variant Found in Childhood Lupus and a Role for PACSIN1/TRAF4 Complex in Toll-like Receptor 7 Activation.
Xie C, Zhou H, Athanasopoulos V, Shen Q, Zhang Y, Meng X, Burgio G, Arsov T, Lungu AC, Zhang P, Qin Y, Ma J, Wu X, Jiang X, Ding H, Meng Y, Shen N, He Y, Vinuesa CG. Xie C, et al. Among authors: shen q, shen n. Arthritis Rheumatol. 2023 Jun;75(6):1058-1071. doi: 10.1002/art.42416. Epub 2023 Mar 30. Arthritis Rheumatol. 2023. PMID: 36622335
Zeb2 drives the formation of CD11c+ atypical B cells to sustain germinal centers that control persistent infection.
Gao X, Shen Q, Roco JA, Dalton B, Frith K, Munier CML, Ballard FD, Wang K, Kelly HG, Nekrasov M, He JS, Jaeger R, Carreira P, Ellyard JI, Beattie L, Enders A, Cook MC, Zaunders JJ, Cockburn IA. Gao X, et al. Among authors: shen q. Sci Immunol. 2024 Mar 29;9(93):eadj4748. doi: 10.1126/sciimmunol.adj4748. Epub 2024 Mar 29. Sci Immunol. 2024. PMID: 38330097
Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity.
Zhang Y, Morris R, Brown GJ, Lorenzo AMD, Meng X, Kershaw NJ, Kiridena P, Burgio G, Gross S, Cappello JY, Shen Q, Wang H, Turnbull C, Lea-Henry T, Stanley M, Yu Z, Ballard FD, Chuah A, Lee JC, Hatch AM, Enders A, Masters SL, Headley AP, Trnka P, Mallon D, Fletcher JT, Walters GD, Šestan M, Jelušić M, Cook MC, Athanasopoulos V, Fulcher DA, Babon JJ, Vinuesa CG, Ellyard JI. Zhang Y, et al. Among authors: shen q. J Exp Med. 2024 Apr 1;221(4):e20221080. doi: 10.1084/jem.20221080. Epub 2024 Feb 28. J Exp Med. 2024. PMID: 38417019
5,785 results