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TLR7 gain-of-function genetic variation causes human lupus.
Brown GJ, Cañete PF, Wang H, Medhavy A, Bones J, Roco JA, He Y, Qin Y, Cappello J, Ellyard JI, Bassett K, Shen Q, Burgio G, Zhang Y, Turnbull C, Meng X, Wu P, Cho E, Miosge LA, Andrews TD, Field MA, Tvorogov D, Lopez AF, Babon JJ, López CA, Gónzalez-Murillo Á, Garulo DC, Pascual V, Levy T, Mallack EJ, Calame DG, Lotze T, Lupski JR, Ding H, Ullah TR, Walters GD, Koina ME, Cook MC, Shen N, de Lucas Collantes C, Corry B, Gantier MP, Athanasopoulos V, Vinuesa CG. Brown GJ, et al. Among authors: shen q, shen n. Nature. 2022 May;605(7909):349-356. doi: 10.1038/s41586-022-04642-z. Epub 2022 Apr 27. Nature. 2022. PMID: 35477763 Free PMC article.
MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis.
Pan W, Zhu S, Dai D, Liu Z, Li D, Li B, Gagliani N, Zheng Y, Tang Y, Weirauch MT, Chen X, Zhu W, Wang Y, Chen B, Qian Y, Chen Y, Fang J, Herbst R, Richman L, Jallal B, Harley JB, Flavell RA, Yao Y, Shen N. Pan W, et al. Among authors: shen n. Nat Commun. 2015 May 12;6:7096. doi: 10.1038/ncomms8096. Nat Commun. 2015. PMID: 25963922 Free article.
Low-dose interleukin-2 treatment selectively modulates CD4(+) T cell subsets in patients with systemic lupus erythematosus.
He J, Zhang X, Wei Y, Sun X, Chen Y, Deng J, Jin Y, Gan Y, Hu X, Jia R, Xu C, Hou Z, Leong YA, Zhu L, Feng J, An Y, Jia Y, Li C, Liu X, Ye H, Ren L, Li R, Yao H, Li Y, Chen S, Zhang X, Su Y, Guo J, Shen N, Morand EF, Yu D, Li Z. He J, et al. Among authors: shen n. Nat Med. 2016 Sep;22(9):991-3. doi: 10.1038/nm.4148. Epub 2016 Aug 8. Nat Med. 2016. PMID: 27500725
A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases.
Zhao J, Ma J, Deng Y, Kelly JA, Kim K, Bang SY, Lee HS, Li QZ, Wakeland EK, Qiu R, Liu M, Guo J, Li Z, Tan W, Rasmussen A, Lessard CJ, Sivils KL, Hahn BH, Grossman JM, Kamen DL, Gilkeson GS, Bae SC, Gaffney PM, Shen N, Tsao BP. Zhao J, et al. Among authors: shen n. Nat Genet. 2017 Mar;49(3):433-437. doi: 10.1038/ng.3782. Epub 2017 Jan 30. Nat Genet. 2017. PMID: 28135245 Free PMC article.
MiR-125a Is a critical modulator for neutrophil development.
Qin Y, Wu L, Ouyang Y, Zhou P, Zhou H, Wang Y, Ma J, Zhang J, Chen Y, Qian J, Tang Y, Shen N. Qin Y, et al. Among authors: shen n. PLoS Genet. 2017 Oct 4;13(10):e1007027. doi: 10.1371/journal.pgen.1007027. eCollection 2017 Oct. PLoS Genet. 2017. PMID: 28976973 Free PMC article.
Association of Abnormal Elevations in IFIT3 With Overactive Cyclic GMP-AMP Synthase/Stimulator of Interferon Genes Signaling in Human Systemic Lupus Erythematosus Monocytes.
Wang J, Dai M, Cui Y, Hou G, Deng J, Gao X, Liao Z, Liu Y, Meng Y, Wu L, Yao C, Wang Y, Qian J, Guo Q, Ding H, Qu B, Shen N. Wang J, et al. Among authors: shen n. Arthritis Rheumatol. 2018 Dec;70(12):2036-2045. doi: 10.1002/art.40576. Epub 2018 Oct 14. Arthritis Rheumatol. 2018. PMID: 29806091
1,609 results