Shen L - Search Results

1

Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-G_i Complex Structures.

Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Brust CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu ZJ. Hua T, et al. Among authors: shen l. Cell. 2020 Feb 20;180(4):655-665.e18. doi: 10.1016/j.cell.2020.01.008. Epub 2020 Jan 30. Cell. 2020. PMID: 32004463 Free PMC article.

2

Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C.

Ganapathy S, Fagman JB, Shen L, Yu T, Zhou X, Dai W, Makriyannis A, Chen C. Ganapathy S, et al. Among authors: shen l. Oncotarget. 2016 Dec 20;7(51):84326-84337. doi: 10.18632/oncotarget.12607. Oncotarget. 2016. PMID: 27741517 Free PMC article.

3

Suppression of PKC causes oncogenic stress for triggering apoptosis in cancer cells.

Ganapathy S, Peng B, Shen L, Yu T, Lafontant J, Li P, Xiong R, Makriyannis A, Chen C. Ganapathy S, et al. Among authors: shen l. Oncotarget. 2017 May 9;8(19):30992-31002. doi: 10.18632/oncotarget.16047. Oncotarget. 2017. PMID: 28415683 Free PMC article.

4

5-HT_2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

Peng Y, McCorvy JD, Harpsøe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjørn-Yoshimoto WE, Ding K, Wacker D, Han GW, Cheng J, Katritch V, Jensen AA, Hanson MA, Zhao S, Gloriam DE, Roth BL, Stevens RC, Liu ZJ. Peng Y, et al. Among authors: shen l. Cell. 2018 Feb 8;172(4):719-730.e14. doi: 10.1016/j.cell.2018.01.001. Epub 2018 Feb 1. Cell. 2018. PMID: 29398112 Free PMC article.

5

A lethal synergy induced by phellinus linteus and camptothecin11 in colon cancer cells.

Yu T, Ganapathy S, Shen L, Peng B, Kim SH, Makriyannis A, Chen C. Yu T, et al. Among authors: shen l. Oncotarget. 2018 Jan 4;9(5):6308-6319. doi: 10.18632/oncotarget.23918. eCollection 2018 Jan 19. Oncotarget. 2018. PMID: 29464074 Free PMC article.

6

Identification of natural products as novel ligands for the human 5-HT_2C receptor.

Peng Y, Zhao S, Wu Y, Cao H, Xu Y, Liu X, Shui W, Cheng J, Zhao S, Shen L, Ma J, Quinn RJ, Stevens RC, Zhong G, Liu ZJ. Peng Y, et al. Among authors: shen l. Biophys Rep. 2018;4(1):50-61. doi: 10.1007/s41048-018-0047-1. Epub 2018 Mar 9. Biophys Rep. 2018. PMID: 29577069 Free PMC article.

7

Computational design of thermostabilizing point mutations for G protein-coupled receptors.

Popov P, Peng Y, Shen L, Stevens RC, Cherezov V, Liu ZJ, Katritch V. Popov P, et al. Among authors: shen l. Elife. 2018 Jun 21;7:e34729. doi: 10.7554/eLife.34729. Elife. 2018. PMID: 29927385 Free PMC article.

8

Structural and Functional Insights into Cannabinoid Receptors.

Li X, Shen L, Hua T, Liu ZJ. Li X, et al. Among authors: shen l. Trends Pharmacol Sci. 2020 Sep;41(9):665-677. doi: 10.1016/j.tips.2020.06.010. Epub 2020 Jul 29. Trends Pharmacol Sci. 2020. PMID: 32739033 Review.

9

Structural insights into the activation of chemokine receptor CXCR2.

Liu K, Shen L, Wu M, Liu ZJ, Hua T. Liu K, et al. Among authors: shen l. FEBS J. 2022 Jan;289(2):386-393. doi: 10.1111/febs.15865. Epub 2021 Apr 21. FEBS J. 2022. PMID: 33835690 Free article. Review.

10

Protocol for crystal structure determination of the antagonist-bound human cannabinoid receptor CB2.

Shen L, Li X, Liu J, Liu K, Liu ZJ, Hua T. Shen L, et al. STAR Protoc. 2021 Jun 7;2(2):100584. doi: 10.1016/j.xpro.2021.100584. eCollection 2021 Jun 18. STAR Protoc. 2021. PMID: 34151302 Free PMC article.

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