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Design, synthesis, and biological evaluation of anti-EV71 agents.
Li P, Yang B, Hao F, Wang P, He H, Huang L, Zhang X, Zhang S, Peng X, Yin K, Hu J, Chen X, Gu Z, Wang L, Shen L, Hu G, Li N, Li J, Chen S, Xiao W, Wang Z, Guo Q, Chang X, Zhang L, Cai Q, Lin T. Li P, et al. Among authors: shen l. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3346-3350. doi: 10.1016/j.bmcl.2016.05.036. Epub 2016 May 14. Bioorg Med Chem Lett. 2016. PMID: 27234148
Michael acceptor in gambogic acid--Its role and application for potent antitumor agents.
Wang J, Shen W, Yuan Z, Lan L, Xu J, Wang C, Ma G, Shi W, Han L, Zhang Z, Hou L, Shen L, Jiang Z, He H, Xiao W, Wang Z, Guo Q, Li J, Chen S. Wang J, et al. Among authors: shen w, shen l. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2844-8. doi: 10.1016/j.bmcl.2015.04.100. Epub 2015 May 11. Bioorg Med Chem Lett. 2015. PMID: 26009165
The approved pediatric drug suramin identified as a clinical candidate for the treatment of EV71 infection-suramin inhibits EV71 infection in vitro and in vivo.
Ren P, Zou G, Bailly B, Xu S, Zeng M, Chen X, Shen L, Zhang Y, Guillon P, Arenzana-Seisdedos F, Buchy P, Li J, von Itzstein M, Li Q, Altmeyer R. Ren P, et al. Among authors: shen l. Emerg Microbes Infect. 2014 Sep;3(9):e62. doi: 10.1038/emi.2014.60. Epub 2014 Sep 3. Emerg Microbes Infect. 2014. PMID: 26038755 Free PMC article.
Discovery and Assessment of Atropisomers of (±)-Lesinurad.
Wang J, Zeng W, Li S, Shen L, Gu Z, Zhang Y, Li J, Chen S, Jia X. Wang J, et al. Among authors: shen l. ACS Med Chem Lett. 2017 Feb 14;8(3):299-303. doi: 10.1021/acsmedchemlett.6b00465. eCollection 2017 Mar 9. ACS Med Chem Lett. 2017. PMID: 28337320 Free PMC article.
Discovery and optimization of selective FGFR4 inhibitors via scaffold hopping.
Wang Y, Chen Z, Dai M, Sun P, Wang C, Gao Y, Zhao H, Zeng W, Shen L, Mao W, Wang T, Hu G, Li J, Chen S, Long C, Chen X, Liu J, Zhang Y. Wang Y, et al. Among authors: shen l. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2420-2423. doi: 10.1016/j.bmcl.2017.04.014. Epub 2017 Apr 5. Bioorg Med Chem Lett. 2017. PMID: 28433531
Discovery of Potent EV71 Capsid Inhibitors for Treatment of HFMD.
Li P, Yu J, Hao F, He H, Shi X, Hu J, Wang L, Du C, Zhang X, Sun Y, Lin F, Gu Z, Xu D, Chen X, Shen L, Hu G, Li J, Chen S, Xiao W, Wang Z, Guo Q, Chang X, Tian X, Lin T. Li P, et al. Among authors: shen l. ACS Med Chem Lett. 2017 Jul 10;8(8):841-846. doi: 10.1021/acsmedchemlett.7b00188. eCollection 2017 Aug 10. ACS Med Chem Lett. 2017. PMID: 28835799 Free PMC article.
Design, Synthesis, and Evaluation of Tetrahydropyrrolo[1,2-c]pyrimidines as Capsid Assembly Inhibitors for HBV Treatment.
Li X, Zhou K, He H, Zhou Q, Sun Y, Hou L, Shen L, Wang X, Zhou Y, Gong Z, He S, Jin H, Gu Z, Zhao S, Zhang L, Sun C, Zheng S, Cheng Z, Zhu Y, Zhang M, Li J, Chen S. Li X, et al. Among authors: shen l. ACS Med Chem Lett. 2017 Aug 24;8(9):969-974. doi: 10.1021/acsmedchemlett.7b00288. eCollection 2017 Sep 14. ACS Med Chem Lett. 2017. PMID: 28947946 Free PMC article.
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