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Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension.
Wang Z, Jiang X, Zhang X, Tian G, Yang R, Wu J, Zou X, Liu Z, Yang X, Wu C, Shi J, Li J, Suo J, Wang Y, Zhang R, Xu Z, Gong X, He Y, Zhu W, Aisa HA, Jiang H, Xu Y, Shen J. Wang Z, et al. Among authors: shen j. J Med Chem. 2019 May 23;62(10):4979-4990. doi: 10.1021/acs.jmedchem.9b00123. Epub 2019 May 8. J Med Chem. 2019. PMID: 31021628
[Spectroscopic studies of aripiprazole].
Li JF, Liu AX, Xia GX, Nian YF, Shen JS. Li JF, et al. Guang Pu Xue Yu Guang Pu Fen Xi. 2007 May;27(5):863-7. Guang Pu Xue Yu Guang Pu Fen Xi. 2007. PMID: 17655090 Chinese.
Sildenafil promotes adipogenesis through a PKG pathway.
Zhang X, Ji J, Yan G, Wu J, Sun X, Shen J, Jiang H, Wang H. Zhang X, et al. Among authors: shen j. Biochem Biophys Res Commun. 2010 Jun 11;396(4):1054-9. doi: 10.1016/j.bbrc.2010.05.064. Epub 2010 May 21. Biochem Biophys Res Commun. 2010. PMID: 20471953
4-Acetyl-2,3,4,5-tetra-hydro-1H-1,4-benzodiazepine.
Zhao QJ, Liu Z, Zheng J, Shen JS. Zhao QJ, et al. Among authors: shen js. Acta Crystallogr Sect E Struct Rep Online. 2008 May 3;64(Pt 6):o969. doi: 10.1107/S1600536808007927. Acta Crystallogr Sect E Struct Rep Online. 2008. PMID: 21202698 Free PMC article.
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