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Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.
Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, Jin K, Nguyen DM, Sands LR, Marchetti F, Abreu MT, Cobb MH, Capobianco AJ, Lee E, Robbins DJ. Li B, et al. Among authors: shen c. Sci Signal. 2017 Jun 27;10(485):eaak9916. doi: 10.1126/scisignal.aak9916. Sci Signal. 2017. PMID: 28655862 Free PMC article.
A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.
Rodriguez-Blanco J, Li B, Long J, Shen C, Yang F, Orton D, Collins S, Kasahara N, Ayad NG, McCrea HJ, Roussel MF, Weiss WA, Capobianco AJ, Robbins DJ. Rodriguez-Blanco J, et al. Among authors: shen c. Clin Cancer Res. 2019 Feb 15;25(4):1379-1388. doi: 10.1158/1078-0432.CCR-18-1319. Epub 2018 Nov 28. Clin Cancer Res. 2019. PMID: 30487124 Free PMC article.
Casein Kinase 1α as a Regulator of Wnt-Driven Cancer.
Shen C, Nayak A, Melendez RA, Wynn DT, Jackson J, Lee E, Ahmed Y, Robbins DJ. Shen C, et al. Int J Mol Sci. 2020 Aug 18;21(16):5940. doi: 10.3390/ijms21165940. Int J Mol Sci. 2020. PMID: 32824859 Free PMC article. Review.
The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling.
Shen C, Nayak A, Neitzel LR, Adams AA, Silver-Isenstadt M, Sawyer LM, Benchabane H, Wang H, Bunnag N, Li B, Wynn DT, Yang F, Garcia-Contreras M, Williams CH, Dakshanamurthy S, Hong CC, Ayad NG, Capobianco AJ, Ahmed Y, Lee E, Robbins DJ. Shen C, et al. Nat Commun. 2021 Sep 6;12(1):5263. doi: 10.1038/s41467-021-25634-z. Nat Commun. 2021. PMID: 34489457 Free PMC article.
Noncanonical activation of GLI signaling in SOX2+ cells drives medulloblastoma relapse.
Swiderska-Syn M, Mir-Pedrol J, Oles A, Schleuger O, Salvador AD, Greiner SM, Seward C, Yang F, Babcock BR, Shen C, Wynn DT, Sanchez-Mejias A, Gershon TR, Martin V, McCrea HJ, Lindsey KG, Krieg C, Rodriguez-Blanco J. Swiderska-Syn M, et al. Among authors: shen c. Sci Adv. 2022 Jul 22;8(29):eabj9138. doi: 10.1126/sciadv.abj9138. Epub 2022 Jul 20. Sci Adv. 2022. PMID: 35857834 Free PMC article.
A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog-Dependent Tumor Growth.
Yang F, Rodriguez-Blanco J, Long J, Swiderska-Syn M, Wynn DT, Li B, Shen C, Nayak A, Ban Y, Sun X, Suter RK, McCrea HJ, Capobianco AJ, Ayad NG, Robbins DJ. Yang F, et al. Among authors: shen c. Mol Cancer Res. 2022 Nov 3;20(11):1598-1610. doi: 10.1158/1541-7786.MCR-22-0182. Mol Cancer Res. 2022. PMID: 35925047 Free PMC article.
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