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Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2.
Cell Chem Biol. 2020 Mar 19;27(3):269-282.e5. doi: 10.1016/j.chembiol.2019.12.008. Epub 2020 Jan 7.
Cell Chem Biol. 2020.
PMID: 31924499
Free PMC article.
Design and Synthesis of Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors.
Huang DS, LeBlanc EV, Shekhar-Guturja T, Robbins N, Krysan DJ, Pizarro J, Whitesell L, Cowen LE, Brown LE.
Huang DS, et al. Among authors: shekhar guturja t.
J Med Chem. 2020 Mar 12;63(5):2139-2180. doi: 10.1021/acs.jmedchem.9b00826. Epub 2019 Sep 26.
J Med Chem. 2020.
PMID: 31513387
Free PMC article.
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Elucidating drug resistance in human fungal pathogens.
Xie JL, Polvi EJ, Shekhar-Guturja T, Cowen LE.
Xie JL, et al. Among authors: shekhar guturja t.
Future Microbiol. 2014;9(4):523-42. doi: 10.2217/fmb.14.18.
Future Microbiol. 2014.
PMID: 24810351
Review.
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Beauvericin Potentiates Azole Activity via Inhibition of Multidrug Efflux, Blocks Candida albicans Morphogenesis, and Is Effluxed via Yor1 and Circuitry Controlled by Zcf29.
Shekhar-Guturja T, Tebung WA, Mount H, Liu N, Köhler JR, Whiteway M, Cowen LE.
Shekhar-Guturja T, et al.
Antimicrob Agents Chemother. 2016 Nov 21;60(12):7468-7480. doi: 10.1128/AAC.01959-16. Print 2016 Dec.
Antimicrob Agents Chemother. 2016.
PMID: 27736764
Free PMC article.
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Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.
Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, Porco JA Jr, Tatu U, Brown LE, Pizarro J, Cowen LE.
Whitesell L, et al. Among authors: shekhar guturja t.
Nat Commun. 2019 Jan 24;10(1):402. doi: 10.1038/s41467-018-08248-w.
Nat Commun. 2019.
PMID: 30679438
Free PMC article.
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Fluorescence Polarization-Based Measurement of Protein-Ligand Interaction in Fungal Cell Lysates.
LeBlanc EV, Shekhar-Guturja T, Whitesell L, Cowen LE.
LeBlanc EV, et al. Among authors: shekhar guturja t.
Curr Protoc. 2021 Jan;1(1):e17. doi: 10.1002/cpz1.17.
Curr Protoc. 2021.
PMID: 33484500
Free PMC article.
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Dual action antifungal small molecule modulates multidrug efflux and TOR signaling.
Shekhar-Guturja T, Gunaherath GM, Wijeratne EM, Lambert JP, Averette AF, Lee SC, Kim T, Bahn YS, Tripodi F, Ammar R, Döhl K, Niewola-Staszkowska K, Schmitt L, Loewith RJ, Roth FP, Sanglard D, Andes D, Nislow C, Coccetti P, Gingras AC, Heitman J, Gunatilaka AA, Cowen LE.
Shekhar-Guturja T, et al.
Nat Chem Biol. 2016 Oct;12(10):867-75. doi: 10.1038/nchembio.2165. Epub 2016 Aug 29.
Nat Chem Biol. 2016.
PMID: 27571477
Free PMC article.
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