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Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury.
Widjaja AA, Dong J, Adami E, Viswanathan S, Ng B, Pakkiri LS, Chothani SP, Singh BK, Lim WW, Zhou J, Shekeran SG, Tan J, Lim SY, Goh J, Wang M, Holgate R, Hearn A, Felkin LE, Yen PM, Dear JW, Drum CL, Schafer S, Cook SA. Widjaja AA, et al. Among authors: shekeran sg. Sci Transl Med. 2021 Jun 9;13(597):eaba8146. doi: 10.1126/scitranslmed.aba8146. Sci Transl Med. 2021. PMID: 34108253
Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts.
Widjaja AA, Viswanathan S, Jinrui D, Singh BK, Tan J, Wei Ting JG, Lamb D, Shekeran SG, George BL, Schafer S, Carling D, Adami E, Cook SA. Widjaja AA, et al. Among authors: shekeran sg. Front Mol Biosci. 2021 Sep 28;8:740650. doi: 10.3389/fmolb.2021.740650. eCollection 2021. Front Mol Biosci. 2021. PMID: 34651016 Free PMC article.
Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury.
Dong J, Lim WW, Shekeran SG, Tan J, Lim SY, Goh JWT, George BL, Schafer S, Cook SA, Widjaja AA. Dong J, et al. Among authors: shekeran sg. Int J Mol Sci. 2022 Jun 25;23(13):7089. doi: 10.3390/ijms23137089. Int J Mol Sci. 2022. PMID: 35806094 Free PMC article.
Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis.
Widjaja AA, Singh BK, Adami E, Viswanathan S, Dong J, D'Agostino GA, Ng B, Lim WW, Tan J, Paleja BS, Tripathi M, Lim SY, Shekeran SG, Chothani SP, Rabes A, Sombetzki M, Bruinstroop E, Min LP, Sinha RA, Albani S, Yen PM, Schafer S, Cook SA. Widjaja AA, et al. Among authors: shekeran sg. Gastroenterology. 2019 Sep;157(3):777-792.e14. doi: 10.1053/j.gastro.2019.05.002. Epub 2019 May 9. Gastroenterology. 2019. PMID: 31078624 Free article.
14 results