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Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors.
J Med Chem. 2008 Sep 25;51(18):5494-7. doi: 10.1021/jm8006068.
J Med Chem. 2008.
PMID: 18800759
Rapamycin biosynthesis: Elucidation of gene product function.
Gregory MA, Hong H, Lill RE, Gaisser S, Petkovic H, Low L, Sheehan LS, Carletti I, Ready SJ, Ward MJ, Kaja AL, Weston AJ, Challis IR, Leadlay PF, Martin CJ, Wilkinson B, Sheridan RM.
Gregory MA, et al. Among authors: sheehan ls.
Org Biomol Chem. 2006 Oct 7;4(19):3565-8. doi: 10.1039/b608813a. Epub 2006 Aug 22.
Org Biomol Chem. 2006.
PMID: 16990929
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Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties.
Schell U, Haydock SF, Kaja AL, Carletti I, Lill RE, Read E, Sheehan LS, Low L, Fernandez MJ, Grolle F, McArthur HA, Sheridan RM, Leadlay PF, Wilkinson B, Gaisser S.
Schell U, et al. Among authors: sheehan ls.
Org Biomol Chem. 2008 Sep 21;6(18):3315-27. doi: 10.1039/b807914e. Epub 2008 Jul 28.
Org Biomol Chem. 2008.
PMID: 18802638
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Engineering of the spinosyn PKS: directing starter unit incorporation.
Sheehan LS, Lill RE, Wilkinson B, Sheridan RM, Vousden WA, Kaja AL, Crouse GD, Gifford J, Graupner PR, Karr L, Lewer P, Sparks TC, Leadlay PF, Waldron C, Martin CJ.
Sheehan LS, et al.
J Nat Prod. 2006 Dec;69(12):1702-10. doi: 10.1021/np0602517.
J Nat Prod. 2006.
PMID: 17190446
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Diversity oriented biosynthesis via accelerated evolution of modular gene clusters.
Wlodek A, Kendrew SG, Coates NJ, Hold A, Pogwizd J, Rudder S, Sheehan LS, Higginbotham SJ, Stanley-Smith AE, Warneck T, Nur-E-Alam M, Radzom M, Martin CJ, Overvoorde L, Samborskyy M, Alt S, Heine D, Carter GT, Graziani EI, Koehn FE, McDonald L, Alanine A, Rodríguez Sarmiento RM, Chao SK, Ratni H, Steward L, Norville IH, Sarkar-Tyson M, Moss SJ, Leadlay PF, Wilkinson B, Gregory MA.
Wlodek A, et al. Among authors: sheehan ls.
Nat Commun. 2017 Oct 31;8(1):1206. doi: 10.1038/s41467-017-01344-3.
Nat Commun. 2017.
PMID: 29089518
Free PMC article.
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