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Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors.
Sci Adv. 2023 Apr 21;9(16):eadg6618. doi: 10.1126/sciadv.adg6618. Epub 2023 Apr 19.
Sci Adv. 2023.
PMID: 37075114
Free PMC article.
Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration.
Lawrence JA, Aguilar-Calvo P, Ojeda-Juárez D, Khuu H, Soldau K, Pizzo DP, Wang J, Malik A, Shay TF, Sullivan EE, Aulston B, Song SM, Callender JA, Sanchez H, Geschwind MD, Roy S, Rissman RA, Trejo J, Tanaka N, Wu C, Chen X, Patrick GN, Sigurdson CJ.
Lawrence JA, et al. Among authors: shay tf.
J Neurosci. 2023 May 24;43(21):3970-3984. doi: 10.1523/JNEUROSCI.1878-22.2023. Epub 2023 Apr 5.
J Neurosci. 2023.
PMID: 37019623
Free PMC article.
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Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates.
Chen X, Wolfe DA, Bindu DS, Zhang M, Taskin N, Goertsen D, Shay TF, Sullivan EE, Huang SF, Ravindra Kumar S, Arokiaraj CM, Plattner VM, Campos LJ, Mich JK, Monet D, Ngo V, Ding X, Omstead V, Weed N, Bishaw Y, Gore BB, Lein ES, Akrami A, Miller C, Levi BP, Keller A, Ting JT, Fox AS, Eroglu C, Gradinaru V.
Chen X, et al. Among authors: shay tf.
Nat Commun. 2023 Jun 8;14(1):3345. doi: 10.1038/s41467-023-38582-7.
Nat Commun. 2023.
PMID: 37291094
Free PMC article.
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Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain.
Chuapoco MR, Flytzanis NC, Goeden N, Christopher Octeau J, Roxas KM, Chan KY, Scherrer J, Winchester J, Blackburn RJ, Campos LJ, Man KNM, Sun J, Chen X, Lefevre A, Singh VP, Arokiaraj CM, Shay TF, Vendemiatti J, Jang MJ, Mich JK, Bishaw Y, Gore BB, Omstead V, Taskin N, Weed N, Levi BP, Ting JT, Miller CT, Deverman BE, Pickel J, Tian L, Fox AS, Gradinaru V.
Chuapoco MR, et al. Among authors: shay tf.
Nat Nanotechnol. 2023 Oct;18(10):1241-1251. doi: 10.1038/s41565-023-01419-x. Epub 2023 Jul 10.
Nat Nanotechnol. 2023.
PMID: 37430038
Free PMC article.
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Fast, accurate ranking of engineered proteins by target-binding propensity using structure modeling.
Ding X, Chen X, Sullivan EE, Shay TF, Gradinaru V.
Ding X, et al. Among authors: shay tf.
Mol Ther. 2024 Apr 6:S1525-0016(24)00219-3. doi: 10.1016/j.ymthe.2024.04.003. Online ahead of print.
Mol Ther. 2024.
PMID: 38582966
Free article.
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Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates.
Chen X, Wolfe DA, Bindu DS, Zhang M, Taskin N, Goertsen D, Shay TF, Sullivan E, Huang SF, Kumar SR, Arokiaraj CM, Plattner V, Campos LJ, Mich J, Monet D, Ngo V, Ding X, Omstead V, Weed N, Bishaw Y, Gore B, Lein ES, Akrami A, Miller C, Levi BP, Keller A, Ting JT, Fox AS, Eroglu C, Gradinaru V.
Chen X, et al. Among authors: shay tf.
bioRxiv [Preprint]. 2023 Jan 13:2023.01.12.523844. doi: 10.1101/2023.01.12.523844.
bioRxiv. 2023.
PMID: 36711773
Free PMC article.
Updated.
Preprint.
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