Shaw RJ - Search Results

1

LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma.

Stein BD, Ferrarone JR, Gardner EE, Chang JW, Wu D, Hollstein PE, Liang RJ, Yuan M, Chen Q, Coukos JS, Sindelar M, Ngo B, Gross SS, Shaw RJ, Zhang C, Asara JM, Moellering RE, Varmus H, Cantley LC. Stein BD, et al. Among authors: shaw rj. Cancer Discov. 2023 Apr 3;13(4):1002-1025. doi: 10.1158/2159-8290.CD-22-0805. Cancer Discov. 2023. PMID: 36715544 Free PMC article.

2

The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.

Karuman P, Gozani O, Odze RD, Zhou XC, Zhu H, Shaw R, Brien TP, Bozzuto CD, Ooi D, Cantley LC, Yuan J. Karuman P, et al. Mol Cell. 2001 Jun;7(6):1307-19. doi: 10.1016/s1097-2765(01)00258-1. Mol Cell. 2001. PMID: 11430832 Free article.

3

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.

Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. Shaw RJ, et al. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3329-35. doi: 10.1073/pnas.0308061100. Epub 2004 Feb 25. Proc Natl Acad Sci U S A. 2004. PMID: 14985505 Free PMC article.

4

The LKB1 tumor suppressor negatively regulates mTOR signaling.

Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. Shaw RJ, et al. Cancer Cell. 2004 Jul;6(1):91-9. doi: 10.1016/j.ccr.2004.06.007. Cancer Cell. 2004. PMID: 15261145 Free article.

5

DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.

Fernandes N, Sun Y, Chen S, Paul P, Shaw RJ, Cantley LC, Price BD. Fernandes N, et al. Among authors: shaw rj. J Biol Chem. 2005 Apr 15;280(15):15158-64. doi: 10.1074/jbc.M412065200. Epub 2005 Feb 15. J Biol Chem. 2005. PMID: 15713674 Free article.

6

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.

Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. Shaw RJ, et al. Science. 2005 Dec 9;310(5754):1642-6. doi: 10.1126/science.1120781. Epub 2005 Nov 24. Science. 2005. PMID: 16308421 Free PMC article.

7

Ras, PI(3)K and mTOR signalling controls tumour cell growth.

Shaw RJ, Cantley LC. Shaw RJ, et al. Nature. 2006 May 25;441(7092):424-30. doi: 10.1038/nature04869. Nature. 2006. PMID: 16724053 Review.

8

Raptor is phosphorylated by cdc2 during mitosis.

Gwinn DM, Asara JM, Shaw RJ. Gwinn DM, et al. Among authors: shaw rj. PLoS One. 2010 Feb 12;5(2):e9197. doi: 10.1371/journal.pone.0009197. PLoS One. 2010. PMID: 20169205 Free PMC article.

9

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.

Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ. Egan DF, et al. Among authors: shaw rj. Science. 2011 Jan 28;331(6016):456-61. doi: 10.1126/science.1196371. Epub 2010 Dec 23. Science. 2011. PMID: 21205641 Free PMC article.

10

Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice.

Shaw RJ, Cantley LC. Shaw RJ, et al. F1000 Biol Rep. 2012;4:2. doi: 10.3410/B4-2. Epub 2012 Jan 3. F1000 Biol Rep. 2012. PMID: 22242042 Free PMC article.

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