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p53 and rapamycin are additive.
Christy B, Demaria M, Campisi J, Huang J, Jones D, Dodds SG, Williams C, Hubbard G, Livi CB, Gao X, Weintraub S, Curiel T, Sharp ZD, Hasty P. Christy B, et al. Among authors: sharp zd. Oncotarget. 2015 Jun 30;6(18):15802-13. doi: 10.18632/oncotarget.4602. Oncotarget. 2015. PMID: 26158292 Free PMC article.
Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors.
Livi CB, Hardman RL, Christy BA, Dodds SG, Jones D, Williams C, Strong R, Bokov A, Javors MA, Ikeno Y, Hubbard G, Hasty P, Sharp ZD. Livi CB, et al. Among authors: sharp zd. Aging (Albany NY). 2013 Feb;5(2):100-10. doi: 10.18632/aging.100533. Aging (Albany NY). 2013. PMID: 23454836 Free PMC article.
mTORC1 and p53: clash of the gods?
Hasty P, Sharp ZD, Curiel TJ, Campisi J. Hasty P, et al. Among authors: sharp zd. Cell Cycle. 2013 Jan 1;12(1):20-5. doi: 10.4161/cc.22912. Cell Cycle. 2013. PMID: 23255104 Free PMC article.
Use of Transgenic Mice in Aging Research.
Richardson A, Heydari AR, Morgan WW, Nelson JF, Sharp ZD, Walter CA. Richardson A, et al. Among authors: sharp zd. ILAR J. 1997;38(3):125-136. ILAR J. 1997. PMID: 11528054 No abstract available.
Rapamycin Prevents Surgery-Induced Immune Dysfunction in Patients with Bladder Cancer.
Svatek RS, Ji N, de Leon E, Mukherjee NZ, Kabra A, Hurez V, Nicolas M, Michalek JE, Javors M, Wheeler K, Sharp ZD, Livi CB, Shu ZJ, Henkes D, Curiel TJ. Svatek RS, et al. Among authors: sharp zd. Cancer Immunol Res. 2019 Mar;7(3):466-475. doi: 10.1158/2326-6066.CIR-18-0336. Epub 2018 Dec 18. Cancer Immunol Res. 2019. PMID: 30563829 Free PMC article. Clinical Trial.
Do p53 stress responses impact organismal aging?
Hasty P, Campisi J, Sharp ZD. Hasty P, et al. Among authors: sharp zd. Transl Cancer Res. 2016 Dec;5(6):685-691. doi: 10.21037/tcr.2016.12.02. Transl Cancer Res. 2016. PMID: 30984573 Free PMC article.
Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs.
Calhoun C, Shivshankar P, Saker M, Sloane LB, Livi CB, Sharp ZD, Orihuela CJ, Adnot S, White ES, Richardson A, Le Saux CJ. Calhoun C, et al. Among authors: sharp zd. J Gerontol A Biol Sci Med Sci. 2016 Feb;71(2):153-60. doi: 10.1093/gerona/glu241. Epub 2015 Jan 7. J Gerontol A Biol Sci Med Sci. 2016. PMID: 25568097 Free PMC article.
eRapa restores a normal life span in a FAP mouse model.
Hasty P, Livi CB, Dodds SG, Jones D, Strong R, Javors M, Fischer KE, Sloane L, Murthy K, Hubbard G, Sun L, Hurez V, Curiel TJ, Sharp ZD. Hasty P, et al. Among authors: sharp zd. Cancer Prev Res (Phila). 2014 Jan;7(1):169-78. doi: 10.1158/1940-6207.CAPR-13-0299. Epub 2013 Nov 26. Cancer Prev Res (Phila). 2014. PMID: 24282255 Free PMC article.
92 results