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BMI-1 extends proliferative potential of human bronchial epithelial cells while retaining their mucociliary differentiation capacity.
Munye MM, Shoemark A, Hirst RA, Delhove JM, Sharp TV, McKay TR, O'Callaghan C, Baines DL, Howe SJ, Hart SL. Munye MM, et al. Among authors: sharp tv. Am J Physiol Lung Cell Mol Physiol. 2017 Feb 1;312(2):L258-L267. doi: 10.1152/ajplung.00471.2016. Epub 2016 Dec 15. Am J Physiol Lung Cell Mol Physiol. 2017. PMID: 27979861 Free PMC article.
A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia.
Foxler DE, Bridge KS, Foster JG, Grevitt P, Curry S, Shah KM, Davidson KM, Nagano A, Gadaleta E, Rhys HI, Kennedy PT, Hermida MA, Chang TY, Shaw PE, Reynolds LE, McKay TR, Wang HW, Ribeiro PS, Plevin MJ, Lagos D, Lemoine NR, Rajan P, Graham TA, Chelala C, Hodivala-Dilke KM, Spendlove I, Sharp TV. Foxler DE, et al. Among authors: sharp tv. EMBO Mol Med. 2018 Aug;10(8):e8304. doi: 10.15252/emmm.201708304. EMBO Mol Med. 2018. PMID: 29930174 Free PMC article.
Human feeder cell line for derivation and culture of hESc/hiPSc.
McKay TR, Camarasa MV, Iskender B, Ye J, Bates N, Miller D, Fitzsimmons JC, Foxler D, Mee M, Sharp TV, Aplin J, Brison DR, Kimber SJ. McKay TR, et al. Among authors: sharp tv. Stem Cell Res. 2011 Sep;7(2):154-62. doi: 10.1016/j.scr.2011.04.005. Epub 2011 May 16. Stem Cell Res. 2011. PMID: 21763623 Free article.
Ajmaline blocks INa and IKr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters.
Miller DC, Harmer SC, Poliandri A, Nobles M, Edwards EC, Ware JS, Sharp TV, McKay TR, Dunkel L, Lambiase PD, Tinker A. Miller DC, et al. Among authors: sharp tv. Stem Cell Res. 2017 Dec;25:233-244. doi: 10.1016/j.scr.2017.11.003. Epub 2017 Nov 7. Stem Cell Res. 2017. PMID: 29172153 Free PMC article.
The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development.
Sharp TV, Al-Attar A, Foxler DE, Ding L, de A Vallim TQ, Zhang Y, Nijmeh HS, Webb TM, Nicholson AG, Zhang Q, Kraja A, Spendlove I, Osborne J, Mardis E, Longmore GD. Sharp TV, et al. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19932-7. doi: 10.1073/pnas.0805003105. Epub 2008 Dec 5. Proc Natl Acad Sci U S A. 2008. PMID: 19060205 Free PMC article.
LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.
James V, Zhang Y, Foxler DE, de Moor CH, Kong YW, Webb TM, Self TJ, Feng Y, Lagos D, Chu CY, Rana TM, Morley SJ, Longmore GD, Bushell M, Sharp TV. James V, et al. Among authors: sharp tv. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12499-504. doi: 10.1073/pnas.0914987107. Epub 2010 Jun 28. Proc Natl Acad Sci U S A. 2010. PMID: 20616046 Free PMC article.
47 results