Sharma SV - Search Results

1

Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo.

Sharma SV, Tong X, Pubill-Ulldemolins C, Cartmell C, Bogosyan EJA, Rackham EJ, Marelli E, Hamed RB, Goss RJM. Sharma SV, et al. Nat Commun. 2017 Aug 9;8(1):229. doi: 10.1038/s41467-017-00194-3. Nat Commun. 2017. PMID: 28794415 Free PMC article.

2

Sonogashira diversification of unprotected halotryptophans, halotryptophan containing tripeptides; and generation of a new to nature bromo-natural product and its diversification in water.

Corr MJ, Sharma SV, Pubill-Ulldemolins C, Bown RT, Poirot P, Smith DRM, Cartmell C, Abou Fayad A, Goss RJM. Corr MJ, et al. Among authors: sharma sv. Chem Sci. 2017 Mar 1;8(3):2039-2046. doi: 10.1039/c6sc04423a. Epub 2016 Nov 11. Chem Sci. 2017. PMID: 28451322 Free PMC article.

3

Mild, Aqueous α-Arylation of Ketones: Towards New Diversification Tools for Halogenated Metabolites and Drug Molecules.

Marelli E, Renault Y, Sharma SV, Nolan SP, Goss RJ. Marelli E, et al. Among authors: sharma sv. Chemistry. 2017 Mar 17;23(16):3832-3836. doi: 10.1002/chem.201700680. Epub 2017 Mar 6. Chemistry. 2017. PMID: 28195381

4

Heck Diversification of Indole-Based Substrates under Aqueous Conditions: From Indoles to Unprotected Halo-tryptophans and Halo-tryptophans in Natural Product Derivatives.

Pubill-Ulldemolins C, Sharma SV, Cartmell C, Zhao J, Cárdenas P, Goss RJM. Pubill-Ulldemolins C, et al. Among authors: sharma sv. Chemistry. 2019 Aug 14;25(46):10866-10875. doi: 10.1002/chem.201901327. Epub 2019 Jul 19. Chemistry. 2019. PMID: 31125453 Free PMC article.

5

Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions.

Renault YJG, Lynch R, Marelli E, Sharma SV, Pubill-Ulldemolins C, Sharp JA, Cartmell C, Cárdenas P, Goss RJM. Renault YJG, et al. Among authors: sharma sv. Chem Commun (Camb). 2019 Nov 12;55(91):13653-13656. doi: 10.1039/c9cc02554e. Chem Commun (Camb). 2019. PMID: 31593201

6

Halogenases: a palette of emerging opportunities for synthetic biology-synthetic chemistry and C-H functionalisation.

Crowe C , Molyneux S , Sharma SV , Zhang Y , Gkotsi DS , Connaris H , Goss RJM . Crowe C , et al. Among authors: sharma sv. Chem Soc Rev. 2021 Sep 7;50(17):9443-9481. doi: 10.1039/d0cs01551b. Epub 2021 Aug 9. Chem Soc Rev. 2021. PMID: 34368824 Free PMC article. Review.

7

GenoChemetic Strategy for Derivatization of the Violacein Natural Product Scaffold.

Lai HE, Obled AMC, Chee SM, Morgan RM, Lynch R, Sharma SV, Moore SJ, Polizzi KM, Goss RJM, Freemont PS. Lai HE, et al. Among authors: sharma sv. ACS Chem Biol. 2021 Nov 19;16(11):2116-2123. doi: 10.1021/acschembio.1c00483. Epub 2021 Oct 14. ACS Chem Biol. 2021. PMID: 34648268 Free PMC article.

8

An expedient, mild and aqueous method for Suzuki-Miyaura diversification of (hetero)aryl halides or (poly)chlorinated pharmaceuticals.

Sharma SV, Pubill-Ulldemolins C, Marelli E, Goss RJM. Sharma SV, et al. Org Chem Front. 2021 Aug 19;8(20):5722-5727. doi: 10.1039/d1qo00919b. eCollection 2021 Oct 12. Org Chem Front. 2021. PMID: 34745636 Free PMC article.

9

Rapid enzyme regeneration results in the striking catalytic longevity of an engineered, single species, biocatalytic biofilm.

Tong X, Barberi TT, Botting CH, Sharma SV, Simmons MJ, Overton TW, Goss RJ. Tong X, et al. Among authors: sharma sv. Microb Cell Fact. 2016 Oct 21;15(1):180. doi: 10.1186/s12934-016-0579-3. Microb Cell Fact. 2016. PMID: 27769259 Free PMC article.

10

A marine viral halogenase that iodinates diverse substrates.

Gkotsi DS, Ludewig H, Sharma SV, Connolly JA, Dhaliwal J, Wang Y, Unsworth WP, Taylor RJK, McLachlan MMW, Shanahan S, Naismith JH, Goss RJM. Gkotsi DS, et al. Among authors: sharma sv. Nat Chem. 2019 Dec;11(12):1091-1097. doi: 10.1038/s41557-019-0349-z. Epub 2019 Oct 14. Nat Chem. 2019. PMID: 31611633 Free PMC article.

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