Sharma RK - Search Results

1

1-[4-(2-Dimethylaminoethoxy)phenylcarbonyl]-3,5-Bis(3,4,5-Trimethoxybenzylidene)- 4-Piperidone Hydrochloride and Related Compounds: Potent Cytotoxins Demonstrate Greater Toxicity to Neoplasms than Non- Malignant Cells.

Roayapalley PK, Dimmock JR, Sakagami H, Okudaira N, Sharma RK, Das U. Roayapalley PK, et al. Among authors: sharma rk. Med Chem. 2022;18(9):1001-1012. doi: 10.2174/1573406418666220322154110. Med Chem. 2022. PMID: 35319387

2

Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds.

Das U, Alcorn J, Shrivastav A, Sharma RK, De Clercq E, Balzarini J, Dimmock JR. Das U, et al. Among authors: sharma rk. Eur J Med Chem. 2007 Jan;42(1):71-80. doi: 10.1016/j.ejmech.2006.08.002. Epub 2006 Sep 22. Eur J Med Chem. 2007. PMID: 16996657

3

N-acyl-3,5-bis(arylidene)-4-piperidones and related compounds which stimulate fyn kinase.

Das U, Selvakumar P, Sharma RK, Haas TA, Dimmock JR. Das U, et al. Among authors: sharma rk. J Enzyme Inhib Med Chem. 2007 Aug;22(4):451-5. doi: 10.1080/14756360701192515. J Enzyme Inhib Med Chem. 2007. PMID: 17847712

4

3,5-Bis(benzylidene)-4-oxo-1-phosphonopiperidines and related diethyl esters: Potent cytotoxins with multi-drug-resistance reverting properties.

Das S, Das U, Selvakumar P, Sharma RK, Balzarini J, De Clercq E, Molnár J, Serly J, Baráth Z, Schatte G, Bandy B, Gorecki DK, Dimmock JR. Das S, et al. Among authors: sharma rk. ChemMedChem. 2009 Nov;4(11):1831-40. doi: 10.1002/cmdc.200900288. ChemMedChem. 2009. PMID: 19802855 Free PMC article.

5

3,5-Bis(benzylidene)-1-[4-2-(morpholin-4-yl)ethoxyphenylcarbonyl]-4-piperidone hydrochloride: a lead tumor-specific cytotoxin which induces apoptosis and autophagy.

Das U, Sakagami H, Chu Q, Wang Q, Kawase M, Selvakumar P, Sharma RK, Dimmock JR. Das U, et al. Among authors: sharma rk. Bioorg Med Chem Lett. 2010 Feb 1;20(3):912-7. doi: 10.1016/j.bmcl.2009.12.076. Epub 2009 Dec 24. Bioorg Med Chem Lett. 2010. PMID: 20064715 Free PMC article.

6

Design, Synthesis and Tumour-Selective Toxicity of Novel 1-[3-{3,5-Bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone Oximes and Related Quaternary Ammonium Salts.

Roayapalley PK, Dimmock JR, Contreras L, Balderrama KS, Aguilera RJ, Sakagami H, Amano S, Sharma RK, Das U. Roayapalley PK, et al. Among authors: sharma rk. Molecules. 2021 Nov 25;26(23):7132. doi: 10.3390/molecules26237132. Molecules. 2021. PMID: 34885719 Free PMC article.

7

Cytotoxic 1,4-bis(2-oxo-1-cycloalkylmethylene)benzenes and related compounds.

Dimmock JR, Jha A, Kumar P, Zello GA, Quail JW, Oloo EO, Oucharek JJ, Pasha MK, Seitz D, Sharma RK, Allen TM, Santos CL, Manavathu EK, De Clercq E, Balzarini J, Stables JP. Dimmock JR, et al. Among authors: sharma rk. Eur J Med Chem. 2002 Jan;37(1):35-44. doi: 10.1016/s0223-5234(01)01294-6. Eur J Med Chem. 2002. PMID: 11841873

8

Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds.

Das U, Gul HI, Alcorn J, Shrivastav A, George T, Sharma RK, Nienaber KH, De Clercq E, Balzarini J, Kawase M, Kan N, Tanaka T, Tani S, Werbovetz KA, Yakovich AJ, Manavathu EK, Stables JP, Dimmock JR. Das U, et al. Among authors: sharma rk. Eur J Med Chem. 2006 May;41(5):577-85. doi: 10.1016/j.ejmech.2005.12.014. Epub 2006 Apr 3. Eur J Med Chem. 2006. PMID: 16581158

9

Cytotoxic thiol alkylators.

Pati HN, Das U, Sharma RK, Dimmock JR. Pati HN, et al. Among authors: sharma rk. Mini Rev Med Chem. 2007 Feb;7(2):131-9. doi: 10.2174/138955707779802642. Mini Rev Med Chem. 2007. PMID: 17305587 Review.

10

E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)-4-piperidones: a topographical study of some novel potent cytotoxins.

Jha A, Mukherjee C, Prasad AK, Parmar VS, Clercq ED, Balzarini J, Stables JP, Manavathu EK, Shrivastav A, Sharma RK, Nienaber KH, Zello GA, Dimmock JR. Jha A, et al. Among authors: sharma rk. Bioorg Med Chem. 2007 Sep 1;15(17):5854-65. doi: 10.1016/j.bmc.2007.05.065. Epub 2007 Jun 2. Bioorg Med Chem. 2007. PMID: 17562365

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