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A model of human neural networks reveals NPTX2 pathology in ALS and FTLD.
Hruska-Plochan M, Wiersma VI, Betz KM, Mallona I, Ronchi S, Maniecka Z, Hock EM, Tantardini E, Laferriere F, Sahadevan S, Hoop V, Delvendahl I, Pérez-Berlanga M, Gatta B, Panatta M, van der Bourg A, Bohaciakova D, Sharma P, De Vos L, Frontzek K, Aguzzi A, Lashley T, Robinson MD, Karayannis T, Mueller M, Hierlemann A, Polymenidou M. Hruska-Plochan M, et al. Among authors: sharma p. Nature. 2024 Feb;626(8001):1073-1083. doi: 10.1038/s41586-024-07042-7. Epub 2024 Feb 14. Nature. 2024. PMID: 38355792 Free PMC article.
Matching tRNA modifications in humans to their known and predicted enzymes.
de Crécy-Lagard V, Boccaletto P, Mangleburg CG, Sharma P, Lowe TM, Leidel SA, Bujnicki JM. de Crécy-Lagard V, et al. Among authors: sharma p. Nucleic Acids Res. 2019 Mar 18;47(5):2143-2159. doi: 10.1093/nar/gkz011. Nucleic Acids Res. 2019. PMID: 30698754 Free PMC article.
A highly conserved tRNA modification contributes to C. albicans filamentation and virulence.
Böttcher B, Kienast SD, Leufken J, Eggers C, Sharma P, Leufken CM, Morgner B, Drexler HCA, Schulz D, Allert S, Jacobsen ID, Vylkova S, Leidel SA, Brunke S. Böttcher B, et al. Among authors: sharma p. Microbiol Spectr. 2024 May 2;12(5):e0425522. doi: 10.1128/spectrum.04255-22. Epub 2024 Apr 8. Microbiol Spectr. 2024. PMID: 38587411 Free PMC article.
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