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TREM-2 plays a protective role in cholestasis by acting as a negative regulator of inflammation.
Labiano I, Agirre-Lizaso A, Olaizola P, Echebarria A, Huici-Izagirre M, Olaizola I, Esparza-Baquer A, Sharif O, Hijona E, Milkiewicz P, Milkiewicz M, González-Romero F, Aspichueta P, Monte MJ, Marin JJG, Vucur M, Luedde T, Marzioni M, Mann DA, Bujanda L, Rodrigues PM, Banales JM, Perugorria MJ. Labiano I, et al. Among authors: sharif o. J Hepatol. 2022 Oct;77(4):991-1004. doi: 10.1016/j.jhep.2022.05.044. Epub 2022 Jun 22. J Hepatol. 2022. PMID: 35750136 Free article.
Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage.
Perugorria MJ, Esparza-Baquer A, Oakley F, Labiano I, Korosec A, Jais A, Mann J, Tiniakos D, Santos-Laso A, Arbelaiz A, Gawish R, Sampedro A, Fontanellas A, Hijona E, Jimenez-Agüero R, Esterbauer H, Stoiber D, Bujanda L, Banales JM, Knapp S, Sharif O, Mann DA. Perugorria MJ, et al. Among authors: sharif o. Gut. 2019 Mar;68(3):533-546. doi: 10.1136/gutjnl-2017-314107. Epub 2018 Jan 27. Gut. 2019. PMID: 29374630 Free PMC article.
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms.
Esparza-Baquer A, Labiano I, Sharif O, Agirre-Lizaso A, Oakley F, Rodrigues PM, Zhuravleva E, O'Rourke CJ, Hijona E, Jimenez-Agüero R, Riaño I, Landa A, La Casta A, Zaki MYW, Munoz-Garrido P, Azkargorta M, Elortza F, Vogel A, Schabbauer G, Aspichueta P, Andersen JB, Knapp S, Mann DA, Bujanda L, Banales JM, Perugorria MJ. Esparza-Baquer A, et al. Among authors: o rourke cj, sharif o. Gut. 2021 Jul;70(7):1345-1361. doi: 10.1136/gutjnl-2019-319227. Epub 2020 Sep 9. Gut. 2021. PMID: 32907830 Free PMC article.
Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages.
Sharif O, Brunner JS, Korosec A, Martins R, Jais A, Snijder B, Vogel A, Caldera M, Hladik A, Lakovits K, Saluzzo S, Boehm B, Gorki AD, Mesteri I, Lindroos-Christensen J, Tillmann K, Stoiber D, Menche J, Schabbauer G, Bilban M, Superti-Furga G, Esterbauer H, Knapp S. Sharif O, et al. Diabetes. 2021 Sep;70(9):2042-2057. doi: 10.2337/db20-0572. Epub 2021 Feb 24. Diabetes. 2021. PMID: 33627323 Free PMC article.
PI3K Signaling in Dendritic Cells Aggravates DSS-Induced Colitis.
Kuttke M, Hromadová D, Yildirim C, Brunner JS, Vogel A, Paar H, Peters S, Weber M, Hofmann M, Kerndl M, Kieler M, Datler H, Musiejovsky L, Salzmann M, Lang M, Soukup K, Halfmann A, Sharif O, Schabbauer G. Kuttke M, et al. Among authors: sharif o. Front Immunol. 2022 Apr 19;13:695576. doi: 10.3389/fimmu.2022.695576. eCollection 2022. Front Immunol. 2022. PMID: 35514976 Free PMC article.
CD14 is a coreceptor of Toll-like receptors 7 and 9.
Baumann CL, Aspalter IM, Sharif O, Pichlmair A, Blüml S, Grebien F, Bruckner M, Pasierbek P, Aumayr K, Planyavsky M, Bennett KL, Colinge J, Knapp S, Superti-Furga G. Baumann CL, et al. Among authors: sharif o. J Exp Med. 2010 Nov 22;207(12):2689-701. doi: 10.1084/jem.20101111. Epub 2010 Nov 15. J Exp Med. 2010. PMID: 21078886 Free PMC article.
Lipid scavenging macrophages and inflammation.
Vogel A, Brunner JS, Hajto A, Sharif O, Schabbauer G. Vogel A, et al. Among authors: sharif o. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Jan;1867(1):159066. doi: 10.1016/j.bbalip.2021.159066. Epub 2021 Oct 6. Biochim Biophys Acta Mol Cell Biol Lipids. 2022. PMID: 34626791 Free article. Review.
76 results