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Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.
Schulte ML, Fu A, Zhao P, Li J, Geng L, Smith ST, Kondo J, Coffey RJ, Johnson MO, Rathmell JC, Sharick JT, Skala MC, Smith JA, Berlin J, Washington MK, Nickels ML, Manning HC. Schulte ML, et al. Among authors: sharick jt. Nat Med. 2018 Feb;24(2):194-202. doi: 10.1038/nm.4464. Epub 2018 Jan 15. Nat Med. 2018. PMID: 29334372 Free PMC article.
Imaging intratumoral metabolic heterogeneity.
Walsh AJ, Sharick JT, Skala MC. Walsh AJ, et al. Among authors: sharick jt. Nat Biomed Eng. 2019 May;3(5):333-334. doi: 10.1038/s41551-019-0398-z. Nat Biomed Eng. 2019. PMID: 31073174 No abstract available.
MEK activation modulates glycolysis and supports suppressive myeloid cells in TNBC.
Franklin DA, Sharick JT, Ericsson-Gonzalez PI, Sanchez V, Dean PT, Opalenik SR, Cairo S, Judde JG, Lewis MT, Chang JC, Sanders ME, Cook RS, Skala MC, Bordeaux J, Orozco Bender J, Vaupel C, Geiss G, Hinerfeld D, Balko JM. Franklin DA, et al. Among authors: sharick jt. JCI Insight. 2020 Aug 6;5(15):e134290. doi: 10.1172/jci.insight.134290. JCI Insight. 2020. PMID: 32634121 Free PMC article.
Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug Treatment.
Sharick JT, Walsh CM, Sprackling CM, Pasch CA, Pham DL, Esbona K, Choudhary A, Garcia-Valera R, Burkard ME, McGregor SM, Matkowskyj KA, Parikh AA, Meszoely IM, Kelley MC, Tsai S, Deming DA, Skala MC. Sharick JT, et al. Front Oncol. 2020 May 15;10:553. doi: 10.3389/fonc.2020.00553. eCollection 2020. Front Oncol. 2020. PMID: 32500020 Free PMC article.
16 results