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Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis.
Becker K, Cao S, Nilsson A, Erlandsson M, Hotop SK, Kuka J, Hansen J, Haldimann K, Grinberga S, Berruga-Fernández T, Huseby DL, Shariatgorji R, Lindmark E, Platzack B, Böttger EC, Crich D, Friberg LE, Vingsbo Lundberg C, Hughes D, Brönstrup M, Andrén PE, Liepinsh E, Hobbie SN. Becker K, et al. Among authors: shariatgorji r. EBioMedicine. 2021 Nov;73:103652. doi: 10.1016/j.ebiom.2021.103652. Epub 2021 Nov 2. EBioMedicine. 2021. PMID: 34740109 Free PMC article.
Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy.
Hulme H, Fridjonsdottir E, Gunnarsdottir H, Vallianatou T, Zhang X, Wadensten H, Shariatgorji R, Nilsson A, Bezard E, Svenningsson P, Andrén PE. Hulme H, et al. Among authors: shariatgorji r. Neurobiol Dis. 2020 Apr;137:104738. doi: 10.1016/j.nbd.2020.104738. Epub 2020 Jan 10. Neurobiol Dis. 2020. PMID: 31927144 Free article.
Cross-validated Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Quantitation Protocol for a Pharmaceutical Drug and Its Drug-Target Effects in the Brain Using Time-of-Flight and Fourier Transform Ion Cyclotron Resonance Analyzers.
Källback P, Vallianatou T, Nilsson A, Shariatgorji R, Schintu N, Pereira M, Barré F, Wadensten H, Svenningsson P, Andrén PE. Källback P, et al. Among authors: shariatgorji r. Anal Chem. 2020 Nov 3;92(21):14676-14684. doi: 10.1021/acs.analchem.0c03203. Epub 2020 Oct 21. Anal Chem. 2020. PMID: 33086792 Free PMC article.
Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice.
Becker K, Aranzana-Climent V, Cao S, Nilsson A, Shariatgorji R, Haldimann K, Platzack B, Hughes D, Andrén PE, Böttger EC, Friberg LE, Hobbie SN; ENABLE consortium. Becker K, et al. Among authors: shariatgorji r. Clin Microbiol Infect. 2021 Sep;27(9):1315-1321. doi: 10.1016/j.cmi.2020.12.004. Epub 2020 Dec 11. Clin Microbiol Infect. 2021. PMID: 33316399 Free article.
Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA-induced dyskinesia.
Fridjonsdottir E, Shariatgorji R, Nilsson A, Vallianatou T, Odell LR, Schembri LS, Svenningsson P, Fernagut PO, Crossman AR, Bezard E, Andrén PE. Fridjonsdottir E, et al. Among authors: shariatgorji r. Sci Adv. 2021 Jan 6;7(2):eabe5948. doi: 10.1126/sciadv.abe5948. Print 2021 Jan. Sci Adv. 2021. PMID: 33523980 Free PMC article.
Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain.
Vallianatou T, Shariatgorji R, Nilsson A, Karlgren M, Hulme H, Fridjonsdottir E, Svenningsson P, Andrén PE. Vallianatou T, et al. Among authors: shariatgorji r. ACS Chem Neurosci. 2021 May 19;12(10):1811-1823. doi: 10.1021/acschemneuro.1c00103. Epub 2021 May 3. ACS Chem Neurosci. 2021. PMID: 33939923 Free PMC article.
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