Sharaky M - Search Results

1

Design and synthesis of novel tetrabromophthalimide derivatives as potential tubulin inhibitors endowed with apoptotic induction for cancer treatment.

Abdel-Motaal M, Aldakhili DA, Abo Elmaaty A, Sharaky M, Mourad MAE, Alzahrani AYA, Mohamed NA, Al-Karmalawy AA. Abdel-Motaal M, et al. Among authors: sharaky m. Drug Dev Res. 2024 Jun;85(4):e22197. doi: 10.1002/ddr.22197. Drug Dev Res. 2024. PMID: 38751223

2

Design and synthesis of novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy.

Abdelrahman NA, Al-Karmalawy AA, Jaballah MY, Yahya G, Sharaky M, Abouzid KAM. Abdelrahman NA, et al. Among authors: sharaky m. RSC Med Chem. 2024 Feb 6;15(3):981-997. doi: 10.1039/d3md00751k. eCollection 2024 Mar 20. RSC Med Chem. 2024. PMID: 38516606

3

Investigating the effect of polymerase inhibitors on cellular proliferation: Computational studies, cytotoxicity, CDK1 inhibitory potential, and LC-MS/MS cancer cell entrapment assays.

Farouk F, Ibrahim IM, Sherif S, Abdelhamed HG, Sharaky M, Al-Karmalawy AA. Farouk F, et al. Among authors: sharaky m. Chem Biol Drug Des. 2024 Mar;103(3):e14500. doi: 10.1111/cbdd.14500. Chem Biol Drug Des. 2024. PMID: 38467555

4

Novel sulfonamide-indolinone hybrids targeting mitochondrial respiration of breast cancer cells.

Helmy SWA, Abdel-Aziz AK, Dokla EME, Ahmed TE, Hatem Y, Abdel Rahman EA, Sharaky M, Shahin MI, Elrazaz EZ, Serya RAT, Henary M, Ali SS, Abou El Ella DA. Helmy SWA, et al. Among authors: sharaky m. Eur J Med Chem. 2024 Mar 15;268:116255. doi: 10.1016/j.ejmech.2024.116255. Epub 2024 Feb 17. Eur J Med Chem. 2024. PMID: 38401190

5

Multi-target rational design and synthesis of novel diphenyl-tethered pyrazolopyrimidines targeting EGFR and topoisomerase II with potential DNA intercalation and apoptosis induction.

Gaber AA, Abo Elmaaty A, Sharaky M, Mosa AA, Yahya Abdullah Alzahrani A, Shaaban S, Eldehna WM, Al-Karmalawy AA. Gaber AA, et al. Among authors: sharaky m. Bioorg Chem. 2024 Apr;145:107223. doi: 10.1016/j.bioorg.2024.107223. Epub 2024 Feb 17. Bioorg Chem. 2024. PMID: 38387399

6

Anticancer effect and laser photostability of ternary graphene oxide/chitosan/silver nanocomposites on various cancer cell lines.

Ramadan MA, Sharaky M, Gad S, Ahmed HA, Jaremko M, Emwas AH, Faid AH. Ramadan MA, et al. Among authors: sharaky m. Nanomedicine (Lond). 2024 Apr;19(8):709-722. doi: 10.2217/nnm-2023-0264. Epub 2024 Feb 7. Nanomedicine (Lond). 2024. PMID: 38323335

7

SIRT1 as a potential key regulator for mediating apoptosis in oropharyngeal cancer using cyclophosphamide and all-trans retinoic acid.

Haggagy MG, Ahmed LA, Sharaky M, Elhefnawi MM, Omran MM. Haggagy MG, et al. Among authors: sharaky m. Sci Rep. 2024 Jan 2;14(1):41. doi: 10.1038/s41598-023-50478-6. Sci Rep. 2024. PMID: 38167952 Free PMC article.

8

Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments.

Al-Karmalawy AA, Mousa MHA, Sharaky M, Mourad MAE, El-Dessouki AM, Hamouda AO, Alnajjar R, Ayed AA, Shaldam MA, Tawfik HO. Al-Karmalawy AA, et al. Among authors: sharaky m. J Med Chem. 2024 Jan 11;67(1):492-512. doi: 10.1021/acs.jmedchem.3c01708. Epub 2023 Dec 20. J Med Chem. 2024. PMID: 38117230

9

Niosomes loading N-acetyl-L-cysteine for cancer treatment in vivo study.

Mohamad EA, Ali AA, Sharaky M, El-Gebaly RH. Mohamad EA, et al. Among authors: sharaky m. Naunyn Schmiedebergs Arch Pharmacol. 2023 Dec 13. doi: 10.1007/s00210-023-02893-9. Online ahead of print. Naunyn Schmiedebergs Arch Pharmacol. 2023. PMID: 38091079

10

Yttrium Oxide nanoparticles induce cytotoxicity, genotoxicity, apoptosis, and ferroptosis in the human triple-negative breast cancer MDA-MB-231 cells.

Emad B, WalyEldeen AA, Hassan H, Sharaky M, Abdelhamid IA, Ibrahim SA, Mohamed HR. Emad B, et al. Among authors: sharaky m. BMC Cancer. 2023 Nov 27;23(1):1151. doi: 10.1186/s12885-023-11649-w. BMC Cancer. 2023. PMID: 38012585 Free PMC article.

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