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Genomics driven precision oncology in advanced biliary tract cancer improves survival.
Kumar-Sinha C, Vats P, Tran N, Robinson DR, Gunchick V, Wu YM, Cao X, Ning Y, Wang R, Rabban E, Bell J, Shankar S, Mannan R, Zhang Y, Zalupski MM, Chinnaiyan AM, Sahai V. Kumar-Sinha C, et al. Among authors: shankar s. Neoplasia. 2023 Aug;42:100910. doi: 10.1016/j.neo.2023.100910. Epub 2023 May 31. Neoplasia. 2023. PMID: 37267699 Free PMC article.
Outlier kinase expression by RNA sequencing as targets for precision therapy.
Kothari V, Wei I, Shankar S, Kalyana-Sundaram S, Wang L, Ma LW, Vats P, Grasso CS, Robinson DR, Wu YM, Cao X, Simeone DM, Chinnaiyan AM, Kumar-Sinha C. Kothari V, et al. Among authors: shankar s. Cancer Discov. 2013 Mar;3(3):280-93. doi: 10.1158/2159-8290.CD-12-0336. Epub 2013 Feb 5. Cancer Discov. 2013. PMID: 23384775 Free PMC article.
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer.
Varambally S, Cao Q, Mani RS, Shankar S, Wang X, Ateeq B, Laxman B, Cao X, Jing X, Ramnarayanan K, Brenner JC, Yu J, Kim JH, Han B, Tan P, Kumar-Sinha C, Lonigro RJ, Palanisamy N, Maher CA, Chinnaiyan AM. Varambally S, et al. Among authors: shankar s. Science. 2008 Dec 12;322(5908):1695-9. doi: 10.1126/science.1165395. Epub 2008 Nov 13. Science. 2008. PMID: 19008416 Free PMC article.
Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.
Robinson DR, Kalyana-Sundaram S, Wu YM, Shankar S, Cao X, Ateeq B, Asangani IA, Iyer M, Maher CA, Grasso CS, Lonigro RJ, Quist M, Siddiqui J, Mehra R, Jing X, Giordano TJ, Sabel MS, Kleer CG, Palanisamy N, Natrajan R, Lambros MB, Reis-Filho JS, Kumar-Sinha C, Chinnaiyan AM. Robinson DR, et al. Among authors: shankar s. Nat Med. 2011 Nov 20;17(12):1646-51. doi: 10.1038/nm.2580. Nat Med. 2011. PMID: 22101766 Free PMC article.
KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation.
Shukla S, Allam US, Ahsan A, Chen G, Krishnamurthy PM, Marsh K, Rumschlag M, Shankar S, Whitehead C, Schipper M, Basrur V, Southworth DR, Chinnaiyan AM, Rehemtulla A, Beer DG, Lawrence TS, Nyati MK, Ray D. Shukla S, et al. Among authors: shankar s. Neoplasia. 2014 Feb;16(2):115-28. doi: 10.1593/neo.14184. Neoplasia. 2014. PMID: 24709419 Free PMC article.
AGO2 promotes tumor progression in KRAS-driven mouse models of non-small cell lung cancer.
Tien JC, Chugh S, Goodrum AE, Cheng Y, Mannan R, Zhang Y, Wang L, Dommeti VL, Wang X, Xu A, Hon J, Kenum C, Su F, Wang R, Cao X, Shankar S, Chinnaiyan AM. Tien JC, et al. Among authors: shankar s. Proc Natl Acad Sci U S A. 2021 May 18;118(20):e2026104118. doi: 10.1073/pnas.2026104118. Proc Natl Acad Sci U S A. 2021. PMID: 33972443 Free PMC article.
An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development.
Shankar S, Tien JC, Siebenaler RF, Chugh S, Dommeti VL, Zelenka-Wang S, Wang XM, Apel IJ, Waninger J, Eyunni S, Xu A, Mody M, Goodrum A, Zhang Y, Tesmer JJ, Mannan R, Cao X, Vats P, Pitchiaya S, Ellison SJ, Shi J, Kumar-Sinha C, Crawford HC, Chinnaiyan AM. Shankar S, et al. Nat Commun. 2020 Jun 4;11(1):2817. doi: 10.1038/s41467-020-16309-2. Nat Commun. 2020. PMID: 32499547 Free PMC article.
Characterization of bone metastases from rapid autopsies of prostate cancer patients.
Mehra R, Kumar-Sinha C, Shankar S, Lonigro RJ, Jing X, Philips NE, Siddiqui J, Han B, Cao X, Smith DC, Shah RB, Chinnaiyan AM, Pienta KJ. Mehra R, et al. Among authors: shankar s. Clin Cancer Res. 2011 Jun 15;17(12):3924-32. doi: 10.1158/1078-0432.CCR-10-3120. Epub 2011 May 9. Clin Cancer Res. 2011. PMID: 21555375 Free PMC article.
Expressed pseudogenes in the transcriptional landscape of human cancers.
Kalyana-Sundaram S, Kumar-Sinha C, Shankar S, Robinson DR, Wu YM, Cao X, Asangani IA, Kothari V, Prensner JR, Lonigro RJ, Iyer MK, Barrette T, Shanmugam A, Dhanasekaran SM, Palanisamy N, Chinnaiyan AM. Kalyana-Sundaram S, et al. Among authors: shankar s. Cell. 2012 Jun 22;149(7):1622-34. doi: 10.1016/j.cell.2012.04.041. Cell. 2012. PMID: 22726445 Free PMC article.
1,562 results