Sham YY - Search Results

1

Fragment-based screening and hit-based substructure search: Rapid discovery of 8-hydroxyquinoline-7-carboxylic acid as a low-cytotoxic, nanomolar metallo β-lactamase inhibitor.

Shin WS, Nguyen ME, Bergstrom A, Jennings IR, Crowder MW, Muthyala R, Sham YY. Shin WS, et al. Among authors: sham yy. Chem Biol Drug Des. 2021 Oct;98(4):481-492. doi: 10.1111/cbdd.13912. Epub 2021 Jul 23. Chem Biol Drug Des. 2021. PMID: 34148302

2

Rapid identification of Keap1-Nrf2 small-molecule inhibitors through structure-based virtual screening and hit-based substructure search.

Zhuang C, Narayanapillai S, Zhang W, Sham YY, Xing C. Zhuang C, et al. Among authors: sham yy. J Med Chem. 2014 Feb 13;57(3):1121-6. doi: 10.1021/jm4017174. Epub 2014 Jan 17. J Med Chem. 2014. PMID: 24417449

3

Cell permeable vanX inhibitors as vancomycin re-sensitizing agents.

Muthyala R, Rastogi N, Shin WS, Peterson ML, Sham YY. Muthyala R, et al. Among authors: sham yy. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2535-8. doi: 10.1016/j.bmcl.2014.03.097. Epub 2014 Apr 8. Bioorg Med Chem Lett. 2014. PMID: 24751446

4

A novel drug discovery strategy: mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways.

Zhuang C, Sheng C, Shin WS, Wu Y, Li J, Yao J, Dong G, Zhang W, Sham YY, Miao Z, Zhang W. Zhuang C, et al. Among authors: sham yy. Oncotarget. 2014 Nov 15;5(21):10830-9. doi: 10.18632/oncotarget.2521. Oncotarget. 2014. PMID: 25350970 Free PMC article.

5

Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.

Muthyala R, Shin WS, Xie J, Sham YY. Muthyala R, et al. Among authors: sham yy. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4320-4. doi: 10.1016/j.bmcl.2015.07.065. Epub 2015 Jul 26. Bioorg Med Chem Lett. 2015. PMID: 26264503

6

Discovery of 1-Hydroxypyridine-2(1H)-thione-6-carboxylic Acid as a First-in-Class Low-Cytotoxic Nanomolar Metallo β-Lactamase Inhibitor.

Shin WS, Bergstrom A, Bonomo RA, Crowder MW, Muthyala R, Sham YY. Shin WS, et al. Among authors: sham yy. ChemMedChem. 2017 Jun 7;12(11):845-849. doi: 10.1002/cmdc.201700182. Epub 2017 May 22. ChemMedChem. 2017. PMID: 28482143 Free PMC article.

7

Maintenance DNA Methyltransferase Activity in the Presence of Oxidized Forms of 5-Methylcytosine: Structural Basis for Ten Eleven Translocation-Mediated DNA Demethylation.

Seiler CL, Fernandez J, Koerperich Z, Andersen MP, Kotandeniya D, Nguyen ME, Sham YY, Tretyakova NY. Seiler CL, et al. Among authors: sham yy. Biochemistry. 2018 Oct 23;57(42):6061-6069. doi: 10.1021/acs.biochem.8b00683. Epub 2018 Oct 8. Biochemistry. 2018. PMID: 30230311 Free PMC article.

8

Modeling and Simulation of hGAT1: A Mechanistic Investigation of the GABA Transport Process.

Zafar S, Nguyen ME, Muthyala R, Jabeen I, Sham YY. Zafar S, et al. Among authors: sham yy. Comput Struct Biotechnol J. 2018 Dec 15;17:61-69. doi: 10.1016/j.csbj.2018.12.003. eCollection 2019. Comput Struct Biotechnol J. 2018. PMID: 30619541 Free PMC article.

9

Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21.

Sahu BS, Rodriguez P, Nguyen ME, Han R, Cero C, Razzoli M, Piaggi P, Laskowski LJ, Pavlicev M, Muglia L, Mahata SK, O'Grady S, McCorvy JD, Baier LJ, Sham YY, Bartolomucci A. Sahu BS, et al. Among authors: sham yy. Cell Rep. 2019 Sep 3;28(10):2567-2580.e6. doi: 10.1016/j.celrep.2019.07.101. Cell Rep. 2019. PMID: 31484069 Free PMC article.

10

Conserved Conformational Hierarchy across Functionally Divergent Glycosyltransferases of the GT-B Structural Superfamily as Determined from Microsecond Molecular Dynamics.

Ramirez-Mondragon CA, Nguyen ME, Milicaj J, Hassan BA, Tucci FJ, Muthyala R, Gao J, Taylor EA, Sham YY. Ramirez-Mondragon CA, et al. Among authors: sham yy. Int J Mol Sci. 2021 Apr 28;22(9):4619. doi: 10.3390/ijms22094619. Int J Mol Sci. 2021. PMID: 33924837 Free PMC article.

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