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IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer.
Mace TA, Shakya R, Pitarresi JR, Swanson B, McQuinn CW, Loftus S, Nordquist E, Cruz-Monserrate Z, Yu L, Young G, Zhong X, Zimmers TA, Ostrowski MC, Ludwig T, Bloomston M, Bekaii-Saab T, Lesinski GB. Mace TA, et al. Among authors: shakya r. Gut. 2018 Feb;67(2):320-332. doi: 10.1136/gutjnl-2016-311585. Epub 2016 Oct 21. Gut. 2018. PMID: 27797936 Free PMC article.
Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia.
Liu X, Pitarresi JR, Cuitiño MC, Kladney RD, Woelke SA, Sizemore GM, Nayak SG, Egriboz O, Schweickert PG, Yu L, Trela S, Schilling DJ, Halloran SK, Li M, Dutta S, Fernandez SA, Rosol TJ, Lesinski GB, Shakya R, Ludwig T, Konieczny SF, Leone G, Wu J, Ostrowski MC. Liu X, et al. Among authors: shakya r. Genes Dev. 2016 Sep 1;30(17):1943-55. doi: 10.1101/gad.283499.116. Epub 2016 Sep 15. Genes Dev. 2016. PMID: 27633013 Free PMC article.
Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia.
Pitarresi JR, Liu X, Sharma SM, Cuitiño MC, Kladney RD, Mace TA, Donohue S, Nayak SG, Qu C, Lee J, Woelke SA, Trela S, LaPak K, Yu L, McElroy J, Rosol TJ, Shakya R, Ludwig T, Lesinski GB, Fernandez SA, Konieczny SF, Leone G, Wu J, Ostrowski MC. Pitarresi JR, et al. Among authors: shakya r. Neoplasia. 2016 Sep;18(9):541-52. doi: 10.1016/j.neo.2016.07.006. Neoplasia. 2016. PMID: 27659014 Free PMC article.
The Exportin-1 Inhibitor Selinexor Exerts Superior Antitumor Activity when Combined with T-Cell Checkpoint Inhibitors.
Farren MR, Hennessey RC, Shakya R, Elnaggar O, Young G, Kendra K, Landesman Y, Elloul S, Crochiere M, Klebanov B, Kashyap T, Burd CE, Lesinski GB. Farren MR, et al. Among authors: shakya r. Mol Cancer Ther. 2017 Mar;16(3):417-427. doi: 10.1158/1535-7163.MCT-16-0498. Epub 2017 Feb 1. Mol Cancer Ther. 2017. PMID: 28148715 Free PMC article.
CD200 promotes immunosuppression in the pancreatic tumor microenvironment.
Choueiry F, Torok M, Shakya R, Agrawal K, Deems A, Benner B, Hinton A, Shaffer J, Blaser BW, Noonan AM, Williams TM, Dillhoff M, Conwell DL, Hart PA, Cruz-Monserrate Z, Bai XF, Carson WE 3rd, Mace TA. Choueiry F, et al. Among authors: shakya r. J Immunother Cancer. 2020 Jun;8(1):e000189. doi: 10.1136/jitc-2019-000189. Epub 2020 Jun 23. J Immunother Cancer. 2020. PMID: 32581043 Free PMC article.
Modeling Human Cancer-induced Cachexia.
Talbert EE, Cuitiño MC, Ladner KJ, Rajasekerea PV, Siebert M, Shakya R, Leone GW, Ostrowski MC, Paleo B, Weisleder N, Reiser PJ, Webb A, Timmers CD, Eiferman DS, Evans DC, Dillhoff ME, Schmidt CR, Guttridge DC. Talbert EE, et al. Among authors: shakya r. Cell Rep. 2019 Aug 6;28(6):1612-1622.e4. doi: 10.1016/j.celrep.2019.07.016. Cell Rep. 2019. PMID: 31390573 Free PMC article.
The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer.
Thies KA, Cole MW, Schafer RE, Spehar JM, Richardson DS, Steck SA, Das M, Lian AW, Ray A, Shakya R, Knoblaugh SE, Timmers CD, Ostrowski MC, Chakravarti A, Sizemore GM, Sizemore ST. Thies KA, et al. Among authors: shakya r. Breast Cancer Res. 2021 Jun 12;23(1):65. doi: 10.1186/s13058-021-01438-3. Breast Cancer Res. 2021. PMID: 34118960 Free PMC article.
163 results