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Structural and Functional Studies of the Daunorubicin Priming Ketosynthase DpsC.
Jackson DR, Shakya G, Patel AB, Mohammed LY, Vasilakis K, Wattana-Amorn P, Valentic TR, Milligan JC, Crump MP, Crosby J, Tsai SC. Jackson DR, et al. Among authors: shakya g. ACS Chem Biol. 2018 Jan 19;13(1):141-151. doi: 10.1021/acschembio.7b00551. Epub 2017 Dec 11. ACS Chem Biol. 2018. PMID: 29161022
Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases.
Barajas JF, Shakya G, Moreno G, Rivera H Jr, Jackson DR, Topper CL, Vagstad AL, La Clair JJ, Townsend CA, Burkart MD, Tsai SC. Barajas JF, et al. Among authors: shakya g. Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4142-E4148. doi: 10.1073/pnas.1609001114. Epub 2017 May 8. Proc Natl Acad Sci U S A. 2017. PMID: 28484029 Free PMC article.
Modeling linear and cyclic PKS intermediates through atom replacement.
Shakya G, Rivera H Jr, Lee DJ, Jaremko MJ, La Clair JJ, Fox DT, Haushalter RW, Schaub AJ, Bruegger J, Barajas JF, White AR, Kaur P, Gwozdziowski ER, Wong F, Tsai SC, Burkart MD. Shakya G, et al. J Am Chem Soc. 2014 Dec 3;136(48):16792-9. doi: 10.1021/ja5064857. Epub 2014 Nov 19. J Am Chem Soc. 2014. PMID: 25406716 Free PMC article.
73 results