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GTP signaling links metabolism, DNA repair, and responses to genotoxic stress.
Zhou W, Zhao Z, Lin A, Yang J, Xu J, Kari WR, Yang A, Li J, Solanki S, Speth J, Walker N, Scott AJ, Kothari AU, Yao Y, Peterson ER, Korimerla N, Werner CK, Liang J, Jacobson J, Palavalasa S, Obrien AM, Elaimy AL, Ferris SP, Zhao SG, Sarkaria JN, Győrffy B, Zhang S, Al-Holou WN, Umemura Y, Morgan MA, Lawrence TS, Lyssiotis CA, Peters-Golden M, Shah YM, Wahl DR. Zhou W, et al. Among authors: shah ym. bioRxiv [Preprint]. 2023 Apr 13:2023.04.12.536297. doi: 10.1101/2023.04.12.536297. bioRxiv. 2023. PMID: 37090571 Free PMC article. Updated. Preprint.
Sulfide oxidation promotes hypoxic angiogenesis and neovascularization.
Kumar R, Vitvitsky V, Seth P, Hiraki HL, Bell H, Andren A, Singhal R, Baker BM, Lyssiotis CA, Shah YM, Banerjee R. Kumar R, et al. Among authors: shah ym. bioRxiv [Preprint]. 2023 Mar 15:2023.03.14.532677. doi: 10.1101/2023.03.14.532677. bioRxiv. 2023. PMID: 36993187 Free PMC article. Updated. Preprint.
BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III.
Chen B, Lynn-Nguyen TM, Jadhav P, Halligan BS, Rossiter NJ, Guerra RM, Koshkin S, Koo I, Morlacchi P, Hanna DA, Lin J, Banerjee R, Pagliarini DJ, Patterson AD, Mosalaganti S, Sexton JZ, Calì T, Lyssiotis CA, Shah YM. Chen B, et al. Among authors: shah ym. bioRxiv [Preprint]. 2024 Feb 4:2024.02.02.578646. doi: 10.1101/2024.02.02.578646. bioRxiv. 2024. PMID: 38352460 Free PMC article. Preprint.
Structural enrichment attenuates colitis-associated colon cancer.
Sykes DJ, Solanki S, Chukkapalli S, Williams K, Newman EA, Resnicow K, Shah YM. Sykes DJ, et al. Among authors: shah ym. bioRxiv [Preprint]. 2024 Feb 16:2024.02.13.580099. doi: 10.1101/2024.02.13.580099. bioRxiv. 2024. PMID: 38405737 Free PMC article. Preprint.
Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer.
Cheng C, Hu J, Mannan R, Bhattacharyya R, Rossiter NJ, Magnuson B, Wisniewski JP, Zheng Y, Xiao L, Li C, Awad D, He T, Bao Y, Zhang Y, Cao X, Wang Z, Mehra R, Morlacchi P, Sahai V, di Magliano MP, Shah YM, Ding K, Qiao Y, Lyssiotis CA, Chinnaiyan AM. Cheng C, et al. Among authors: shah ym. bioRxiv [Preprint]. 2024 Mar 20:2024.03.18.585580. doi: 10.1101/2024.03.18.585580. bioRxiv. 2024. PMID: 38562800 Free PMC article. Preprint.
Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer.
DeAngelo SL, Dziechciarz S, Solanki S, Shin M, Zhao L, Balia A, El-Derany MO, Das NK, Castillo C, Bell HN, Paulo JA, Zhang Y, Rossiter NJ, McCulla EC, He J, Talukder I, Schafer ZT, Neamati N, Mancias JD, Koutmos M, Shah YM. DeAngelo SL, et al. Among authors: shah ym. bioRxiv [Preprint]. 2024 Apr 1:2024.03.29.587381. doi: 10.1101/2024.03.29.587381. bioRxiv. 2024. PMID: 38617233 Free PMC article. Preprint.
Fmo5 plays a sex-specific role in goblet cell maturation and mucus barrier formation.
Schaller ML, Sykes ML, Mecano J, Solanki S, Huang W, Rebernick RJ, Beydoun S, Wang E, Bugarin-Lapuz A, Shah YM, Leiser SF. Schaller ML, et al. Among authors: shah ym. bioRxiv [Preprint]. 2024 Apr 10:2024.04.05.588360. doi: 10.1101/2024.04.05.588360. bioRxiv. 2024. PMID: 38645243 Free PMC article. Preprint.
Sulfide oxidation promotes hypoxic angiogenesis and neovascularization.
Kumar R, Vitvitsky V, Sethaudom A, Singhal R, Solanki S, Alibeckoff S, Hiraki HL, Bell HN, Andren A, Baker BM, Lyssiotis CA, Shah YM, Banerjee R. Kumar R, et al. Among authors: shah ym. Nat Chem Biol. 2024 Mar 20. doi: 10.1038/s41589-024-01583-8. Online ahead of print. Nat Chem Biol. 2024. PMID: 38509349
174 results