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Discovery of orally active, potent, and selective benzotriazole-based PTP1B inhibitors.
Patel D, Jain M, Shah SR, Bahekar R, Jadav P, Darji B, Siriki Y, Bandyopadhyay D, Joharapurkar A, Kshirsagar S, Patel H, Shaikh M, Sairam KV, Patel P. Patel D, et al. Among authors: shah sr. ChemMedChem. 2011 Jun 6;6(6):1011-6. doi: 10.1002/cmdc.201100077. Epub 2011 Apr 19. ChemMedChem. 2011. PMID: 21506278 No abstract available.
Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent.
Pingali H, Jain M, Shah S, Basu S, Makadia P, Goswami A, Zaware P, Patil P, Godha A, Giri S, Goel A, Patel M, Patel H, Patel P. Pingali H, et al. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5586-90. doi: 10.1016/j.bmcl.2008.08.112. Epub 2008 Sep 3. Bioorg Med Chem Lett. 2008. PMID: 18805005
Modulation of PPAR subtype selectivity. Part 2: Transforming PPARα/γ dual agonist into α selective PPAR agonist through bioisosteric modification.
Zaware P, Shah SR, Pingali H, Makadia P, Thube B, Pola S, Patel D, Priyadarshini P, Suthar D, Shah M, Jamili J, Sairam KV, Giri S, Patel L, Patel H, Sudani H, Patel H, Jain M, Patel P, Bahekar R. Zaware P, et al. Among authors: shah sr, shah m. Bioorg Med Chem Lett. 2011 Jan 15;21(2):628-32. doi: 10.1016/j.bmcl.2010.12.032. Epub 2010 Dec 10. Bioorg Med Chem Lett. 2011. PMID: 21195611
Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists.
Makadia P, Shah SR, Pingali H, Zaware P, Patel D, Pola S, Thube B, Priyadarshini P, Suthar D, Shah M, Giri S, Trivedi C, Jain M, Patel P, Bahekar R. Makadia P, et al. Among authors: shah sr, shah m. Bioorg Med Chem. 2011 Jan 15;19(2):771-82. doi: 10.1016/j.bmc.2010.12.023. Epub 2010 Dec 13. Bioorg Med Chem. 2011. PMID: 21215640
Long-acting peptidomimetics based DPP-IV inhibitors.
Jadav P, Bahekar R, Shah SR, Patel D, Joharapurkar A, Kshirsagar S, Jain M, Shaikh M, Sairam KV. Jadav P, et al. Among authors: shah sr. Bioorg Med Chem Lett. 2012 May 15;22(10):3516-21. doi: 10.1016/j.bmcl.2012.03.078. Epub 2012 Mar 28. Bioorg Med Chem Lett. 2012. PMID: 22503246
Peptidomimetics as potent and selective PTP1B inhibitors.
Patel D, Jain M, Shah SR, Bahekar R, Jadav P, Shah K, Joharapurkar A, Shaikh M, Sairam KV. Patel D, et al. Among authors: shah k, shah sr. Med Chem. 2013 Aug;9(5):660-71. doi: 10.2174/1573406411309050005. Med Chem. 2013. PMID: 23030658
456 results