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Succination inactivates gasdermin D and blocks pyroptosis.
Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, Shaffer SA, Dutta R, Ionete C, Pesiridis S, Yang S, Thompson PR, Fitzgerald KA. Humphries F, et al. Among authors: shaffer sa. Science. 2020 Sep 25;369(6511):1633-1637. doi: 10.1126/science.abb9818. Epub 2020 Aug 20. Science. 2020. PMID: 32820063 Free PMC article.
Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling.
Paquette N, Conlon J, Sweet C, Rus F, Wilson L, Pereira A, Rosadini CV, Goutagny N, Weber AN, Lane WS, Shaffer SA, Maniatis S, Fitzgerald KA, Stuart L, Silverman N. Paquette N, et al. Among authors: shaffer sa. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12710-5. doi: 10.1073/pnas.1008203109. Epub 2012 Jul 16. Proc Natl Acad Sci U S A. 2012. PMID: 22802624 Free PMC article.
Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells.
Shmuel-Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, Ketelut-Carneiro N, Foley SE, Pechhold S, Houghton J, Muneeruddin K, Shaffer SA, McCormick BA, Reboldi A, Ward D, Marshak-Rothstein A, Fitzgerald KA. Shmuel-Galia L, et al. Among authors: shaffer sa. Immunity. 2021 Jun 8;54(6):1137-1153.e8. doi: 10.1016/j.immuni.2021.05.008. Epub 2021 May 28. Immunity. 2021. PMID: 34051146 Free PMC article.
Proximity-Dependent Labeling of Cysteines.
Sen S, Sultana N, Shaffer SA, Thompson PR. Sen S, et al. Among authors: shaffer sa. J Am Chem Soc. 2021 Nov 24;143(46):19257-19261. doi: 10.1021/jacs.1c07069. Epub 2021 Nov 11. J Am Chem Soc. 2021. PMID: 34762412 Free PMC article.
167 results